Other Chemokine-related Ligands and Receptors

Chemerin, also known as tazarotene-induced gene 2, (TIG2), is a member of the cystatin superfamily. Members of this superfamily contain at least two intrachain disulfide bonds and an alpha-helical structure over a distance of about 100 amino acids. Chemerin is synthesized as a 163 aa precursor that contains a hydrophobic 20 aa N-terminal sequence, an intervening 137 aa cystatin-fold containing domain, and a six aa C-terminal prosegment. The 137 aa mature segment is known to bind to the G protein-coupled receptor, ChemR23.