Inflammatory dendritic cells differentiate from blood monocytes at sites of inflammation and are therefore frequently called monocyte-derived dendritic cells. These cells are not present in steady-state tissues or lymphoid organs but are present in inflamed tissues following infection or injury. Inflammatory dendritic cells have been shown to be capable of stimulating effector T cell differentiation in both the draining lymph nodes and in inflamed tissues. In mice, inflammatory dendritic cells are identified based on their expression of CD11b/Integrin alpha M, CD11c, F4/80, Ly-6C, MHC class II, and CD64/Fc gamma RI and lack of expression of lineage markers. Additional markers include CD107b/Mac-3, Fc epsilon RI alpha, and MMR/CD206. In humans, inflammatory dendritic cells have been characterized as CD1a+, CD1c/BDCA1+, CD11b/Integrin alpha M+, CD11c+, CD14+, CD64/Fc gamma RI+, Fc epsilon RI alpha+, HLA-DR+, MMR/CD206+, and SIRP alpha/CD172a+ cells that lack expression of lineage markers.
Human and Mouse Dendritic Cell Subsets Poster