Mouse Lymphoid Tissue Classical Dendritic Cell Subset Markers
Click on one of the dendritic cell types shown in the buttons below to see the markers that are commonly used to identify the different dendritic cell subsets.
Overview
Two subsets of lymphoid tissue-resident classical dendritic cell (cDC) subsets have been characterized in mice, CD8 alpha+ cDCs and CD11b+ cDCs. While both of these subsets express CD11c and MHC class II, they can be distinguished from each other based on a number of other markers. CD8 alpha+ cDCs express CD8 alpha, CLEC9a, IGSF4A/SynCAM1/Necl2, and XCR1 and lack expression of CD11b/Integrin alpha M, DCIR-2, DC-SIGN/CD209, F4/80, and SIRP alpha/CD172. In contrast, CD11b+ cDCs express CD11b/Integrin alpha M, DCIR2, DC-SIGN/CD209, F4/80, and SIRP alpha/CD172a and lack expression of CD8 alpha, CLEC9a, IGSF4A/SynCAM1/Necl2, and XCR1. Functionally, these two subsets are also distinct. CD8 alpha+ cDCs are known to cross-present antigens to CD8+ T cells and prime Th1 and cytotoxic T cell responses, while CD11b+ cDCs preferentially activate CD4+ T cells and promote Th2- or Th17-driven immune responses.
