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Hematopoietic Stem Cell Markers

Click on one of the stem cell types shown in the buttons below to see the markers that are commonly used to identify each cell type.

Property title
Cell Surface Markers
Cell Surface Markers
ABCG2
ABCG2
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C1q R1/CD93
C1q R1/CD93
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CD34
CD34
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CD38
CD38
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CD43
CD43
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CD44
CD44
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CD48
CD48
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CD90/Thy1
CD90/Thy1
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CD117/c-kit
CD117/c-kit
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CD133
CD133
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CD150/SLAM
CD150/SLAM
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CDCP1
CDCP1
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CXCR4
CXCR4
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Flt-3/Flk-2
Flt-3/Flk-2
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Neprilysin/CD10
Neprilysin/CD10
Sca-1+ , Lin- (mouse)
Sca-1+ , Lin- (mouse)
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VEGF R2/KDR/Flk-1
VEGF R2/KDR/Flk-1
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Intracellular Markers
Intracellular Markers
BMI-1
BMI-1
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ETV6/TEL
ETV6/TEL
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GATA-2
GATA-2
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GFI-1
GFI-1
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HoxB4
HoxB4
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Mcl-1
Mcl-1
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PTEN
PTEN
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STAT5
STAT5

Overview

Hematopoietic stem cells (HSCs) are progenitor cells found in the blood and bone marrow. These multipotent, self-renewing cells give rise to all the cell types found in the blood, including red blood cells, white blood cells, and platelets. Levels of these progenitor cells play a role in cancers of the blood, autoimmune diseases, hematopoiesis, and cell therapies.

Data Examples

Detection of Human Umbilical Cord-derived Hematopoietic Progenitor Cells by Flow Cytometry. Human umbilical cord blood cells were stained using reagents supplied in the Human Hematopoietic Progenitor Cell Multi-Color Flow Kit (R&D Systems, Catalog # FMC019). Cells negative for CD11b/Integrin alpha M and negative/low for CD38 (shown in the boxed area in part A) were gated and assessed for positive expression of CD34 and CD117/c-kit/SCF R (upper right quadrant in part B). Quadrants were set based on staining with the appropriate isotype controls.

Detection of Cell Surface Markers on Hematopoietic Progenitor Cells by Flow Cytometry. Human umbilical cord blood cells were stained with the indicated antibodies included in the Human Hematopoietic Progenitor Cell Multi-Color Flow Kit (R&D Systems, Catalog # FMC019). Representative expression of each analyte in the total umbilical cord blood cell population (filled histograms) is shown over staining with the appropriate isotype controls (open histograms).