The Human Chemokine System

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Chemokine-guided Immune Cell Migration in Lymph Nodes

The principal function of secondary lymphoid organs, such as the lymph nodes, is to bring antigen-presenting cells and antigen-specific B and T cells into close physical contact with each other. This complex cellular rendezvous is critical for mounting an effective immune response. Cells often travel great distances to reach these specialized organs and make precise moves to different regions within them, guided only by a complicated set of highly redundant factors called chemokines.

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