7 results for "ADAM Inhibitors Small Molecules and Peptides" in Products
ADAM Inhibitors Small Molecules and Peptides
ADAMs (a disintegrin and metalloproteases) are a family of transmembrane metalloproteinases that function as proteases and/or adhesion molecules. They are members of the M12B adamalysin protease subfamily, which also includes reprolysins and ADAMTs. There have been 25 human ADAM genes identified to date, 21 of them are functional, and 13 have proteolytic activity. The ADAMs with proteolytic activity are ADAMDEC-1, ADAM-8, 9, 10, 12, 15, 17, 19, 20, 21, 28, 30 and 33, while ADAM-2, 7, 11, 18, ...
Selective ADAM10 metalloprotease inhibitor
| Chemical Name: | (2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-2-[(1S)-1-(N-hydroxyformamido)ethyl]-5-phenylpentanamide |
| Purity: | ≥98% |
Potent ADAM10 and ADAM17 inhibitor
| Chemical Name: | Phenylmethyl N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]carbamate |
| Purity: | ≥98% |
ADAM-17 (TACE) and MMP inhibitor
| Alternate Names: | TNF-α processing inhibitor-0 |
| Chemical Name: | N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide |
| Purity: | ≥95% |
Adam 17 (TACE) and MMP inhibitor; orally bioavailable
| Chemical Name: | (3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide |
| Purity: | ≥98% |
ADAM-17 (TACE) and MMP inhibitor
| Chemical Name: | N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide |
| Purity: | ≥95% |
ADAM-17 (TACE) and MMP inhibitor
| Chemical Name: | N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide |
| Purity: | ≥95% |
Potent ADAMTS7 and ADAMTS12 inhibitor
| Chemical Name: | 5,6-Difluoro-N-[[(4S)-4-(1-methyl-1H-pyrazol-5-yl)-2,5-dioxo-4-imidazolidinyl]methyl]-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamide |
| Purity: | ≥98% |
