Adenosine A2b Receptor Antagonists Small Molecules and Peptides

Adenosine A_2B receptors are members of the adenosine receptor group of G-protein-coupled receptors that also includes A₁, A_2A and A₃. A_2B receptors display high expression levels in the cecum, colon and bladder, with lower levels found in the lung, blood vessels, eye, median eminence and mast cells. A_2B receptors play a role in the relaxation of smooth muscle in the vasculature and intestines, inhibit monocyte and macrophage function and stimulate mast cell mediator release. The human A_2B ...