7 results for "CRF1 Receptor Antagonists Small Molecules and Peptides" in Products

CRF1 Receptor Antagonists Small Molecules and Peptides

The corticotropin-releasing factor (CRF) 1 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF2. It is abundantly expressed in the CNS with major expression in the cortex, cerebellum, hippocampus, amygdala, olfactory bulb and pituitary. In the periphery the receptors are expressed at low levels in the skin, ovary, testis and adrenal gland.

Potent and selective CRF1 antagonist; anxiolytic

Chemical Name: 8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine
Purity: ≥98%
Potent and selective CRF1 antagonist; anxiolytic
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Potent and selective CRF1 antagonist; binds at an allosteric site

Chemical Name: N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine hydrochloride
Purity: ≥98%
Potent and selective CRF1 antagonist; binds at an allosteric site
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CRF1 antagonist

Chemical Name: N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
Purity: ≥98%
CRF1 antagonist
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Selective non-peptide CRF1 antagonist

Chemical Name: 5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride
Purity: ≥98%
Selective non-peptide CRF1 antagonist
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Selective, non-peptide CRF1 antagonist

Chemical Name: N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
Purity: ≥98%
Selective, non-peptide CRF1 antagonist
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Potent and selective CRF1 antagonist

Chemical Name: (7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride
Purity: ≥98%
Potent and selective CRF1 antagonist
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High affinity CRF1 antagonist; orally bioavailable

Chemical Name: 3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine hydrochloride
Purity: ≥98%
High affinity CRF1 antagonist; orally bioavailable
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