5 results for "Group II mGluR Modulators" in Products
Group II mGluR Modulators
Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu2 and mGlu3. mGlu group II receptors are coupled to Gi/o, which inhibits adenylyl cyclase, decreasing the formation of cAMP. These receptors are involved in presynaptic inhibition and do not appear to affect postsynaptic membrane potential by themselves. The human genes for mGlu2 and mGlu3 receptors have been localized to chromosomes 3 (p21.1) and 7 (7q21.1-q21.2) respectively.
Potent and selective negative allosteric modulator of mGlu2 receptors
| Purity: | ≥98% |
Selective positive allosteric modulator of mGlu2 receptors
| Chemical Name: | 2,2,2-Trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)ethanesulfonamide hydrochloride |
| Purity: | ≥98% |
Selective positive allosteric modulator of mGlu2 receptors
| Alternate Names: | Biphenyl-indanone A |
| Chemical Name: | 3'-[[(2-Cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylic acid |
| Purity: | ≥98% |
Selective negative allosteric modulator of group II mGlu receptors
| Chemical Name: | 4-(8-Bromo-2,3-dihydro-2-oxo-1H-1,5-benzodiazepin-4-yl)-2-pyridinecarbonitrile |
| Purity: | ≥98% |
Selective positive allosteric modulator of mGlu2 receptors
| Chemical Name: | (2S)-2-[[4-(1,1-Dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methylimidazo[2,1-b]oxazole-6-carboxamide |
| Purity: | ≥98% |
