6 results for "Nicotinic (a7) Receptor Modulators" in Products

Nicotinic (a7) Receptor Modulators

α7 is a subunit of the neuronal nicotinic receptor that can combine to form homomeric receptors. In avian tissue α7α8 heteromers also occur and an association between α7 and β2 subunits has been suggested in the mammalian brain. The α7 nAChR is particularly prominent in the hippocampus, where it is found on GABAergic interneurons of stratum oriens and stratum radiatum, and on pyramidal neurones.

Presynaptic α7 nAChRs are present on glutamate terminals and ...

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Positive allosteric modulator of α7 nAChRs; active in vivo

Chemical Name: N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea
Purity: ≥98%
Positive allosteric modulator of α7 nAChRs; active in vivo
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Positive allosteric modulator of α7 nAChRs; active in vivo

Chemical Name: N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea
Purity: ≥98%
Positive allosteric modulator of α7 nAChRs; active in vivo
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Positive allosteric modulator of α7 nAChRs

Alternate Names: XY 4083
Chemical Name: [N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide
Positive allosteric modulator of α7 nAChRs
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Allosteric potentiator of α7, α4β2 and α4β4 nAChRs

Chemical Name: [2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienylmethanone
Purity: ≥98%
Allosteric potentiator of α7, α4β2 and α4β4 nAChRs
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Positive allosteric modulator of α7 nAChRs

Chemical Name: 4-[5-(4-Chlorophenyl)-2-methyl-3-(1-oxopropyl)-1H-pyrrol-1-yl]benzenesulfonamide
Purity: ≥97%
Positive allosteric modulator of α7 nAChRs
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Positive allosteric modulator of α7 nAChRs; analgesic

Alternate Names: (-)-(S)-B 973B
Chemical Name: 3,4-Difluoro-N-[(1S)-1-[6-[4-(2-pyridinyl)-1-piperazinyl]-2-pyrazinyl]ethyl]benzenepropanamide
Purity: ≥98%
Positive allosteric modulator of α7 nAChRs; analgesic
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