7 results for "Orexin R1/HCRTR1 Small Molecules and Peptides" in Products

Orexin R1/HCRTR1 Small Molecules and Peptides

HCRTR1, or orexin 1 receptor (OX1R), is a G-protein coupled receptor expressed in the hypothalamus and involved in the regulation of feeding behaviour. HCRTR1 selectively binds the orexin A neuropeptide. It shares 64% identity with HCRTR2. [provided by RefSeq]

Potent, dual orexin receptor antagonist

Chemical Name: N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide
Purity: ≥98%
Potent, dual orexin receptor antagonist
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Potent, dual orexin receptor antagonist

Chemical Name: (2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide
Purity: ≥98%
Potent, dual orexin receptor antagonist
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Potent and selective non-peptide OX1 antagonist

Chemical Name: [5-(2-Fluorophenyl)-2-methyl-4-thiazolyl][2(S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl-1-pyrrolidinyl]methanone
Potent and selective non-peptide OX1 antagonist
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Potent and selective OX1 antagonist

Chemical Name: (aR,1S)-1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-N-(1-methylethyl)-a-phenyl-2(1H)-isoquinolineacetamide
Purity: ≥98%
Potent and selective OX1 antagonist
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Potent and selective peptide OX1 agonist

Purity: ≥95%
Potent and selective peptide OX1 agonist
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Selective non-peptide OX1 antagonist

Chemical Name: N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea
Purity: ≥98%
Selective non-peptide OX1 antagonist
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Selective non-peptide OX1 antagonist

Chemical Name: N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]urea
Purity: ≥98%
Selective non-peptide OX1 antagonist
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