p38 delta: Products

The p38 Mitogen-activated Protein Kinases (MAPKs) are a family of four related Ser/Thr kinases activated by proinflammatory cytokines and environmental stresses.

The most frequently analyzed family member, p38 alpha, also known as SAPK2a and MAPK14, was initially purified as a kinase critical to the signaling cascade linking IL-1 to MAPKAPK-2 and the small heat shock protein HSP27. Ubiquitously expressed, p38 alpha is dually phosphorylated by MKK3 and MKK6 at Thr180 and Tyr182. Once activated, p38 alpha phosphorylates a number of targets, including the cytoplasmic kinases MNK 4 and PRAK5 and the nuclear transcription factors ATF2 1 and STAT1. Several promising compounds that inhibit p38 alpha are being investigated as potential therapies for arthritic and inflammatory diseases.

"p38 delta" has 12 results in Products.
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SB 203580 

Selective inhibitor of p38 MAPK

BIRB 796 

High affinity and selective p38 kinase inhibitor

U0126 

Potent, selective inhibitor of MEK1 and 2

(-)-Cannabidiol 

Natural cannabinoid; GPR55 antagonist, weak CB1 antagonist, CB2 inverse agonist and AMT inhibitor

LY 364947 

Selective inhibitor of TGF-βRI

1-Naphthyl PP1 

Src family kinase inhibitor; also inhibits c-Abl

PD 184352 

Selective MEK inhibitor

ML 3403 

p38 inhibitor

SB 706504 

p38 MAPK inhibitor

Medetomidine hydrochloride 

Potent and highly selective α2 agonist

SJFδ 

Potent and selective p38δ PROTAC®
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