7 results for "RIP Kinase Inhibitors Small Molecules and Peptides" in Products
RIP Kinase Inhibitors Small Molecules and Peptides
Receptor Interacting Protein (RIP) kinases are characterized by a homologous kinase domain, but have distinct non-kinase regions, which are key to the specific function of each RIP kinase. They have key roles in various biological processes, including innate immunity, inflammation and regulation of cell death.
RIP1-5 all have a N-terminal kinase domain. In addition to the kinase domain RIP1 contains an intermediate domain and a C-terminal death domain (DD), which binds to death receptors, ...
RIP1 kinase inhibitor; inhibits necroptosis
| Chemical Name: | 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone |
| Purity: | ≥98% |
Potent RIPK2 inhibitor; orally bioavailable and cell permeable
| Chemical Name: | 6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine |
| Purity: | ≥98% |
Potent and selective RIP3 kinase inhibitor
| Chemical Name: | N-5-Benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine |
| Purity: | ≥98% |
RIPK2 modulator; pro-drug of cRIPGM; orally bioavailable and brain penetrant
| Chemical Name: | N-[1,4-Dihydro-1,4-dioxo-3-[(phenylmethyl)amino]-2-naphthalenyl]-N-[(4-fluorophenyl)methyl]acetamide |
| Purity: | ≥98% |
Potent and metabolically stable RIP1 kinase inhibitor
| Chemical Name: | N-Hydroxy-2,2-dimethyl-N-(phenylmethyl)butanamide |
| Purity: | ≥98% |
Potent RIPK2 inhibitor
| Chemical Name: | 3-(Benzoylamino)-4-methyl-N-[3-(1-methyl-1H-imidazol-2-yl)phenyl]benzamide |
| Purity: | ≥98% |
Potent and selective RIPK3 inhibitor; also blocks activation of necroptosis
| Chemical Name: | 3-(3-Hydroxyphenyl)-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino]-1,6-naphthyridin-2(1H)-one dihydrochloride |
| Purity: | ≥98% |
