Human Neprilysin/CD10 Alexa Fluor® 350-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Neprilysin/CD10

Neprilysin/CD10, also known as NEP and neutral endopeptidase 24.11, is a zinc metallopeptidase expressed at the cell surface of a variety of cells. The enzyme functions both as an endopeptidase with a thermolysin-like specificity and as a dipeptidylcarboxypeptidase. NEP has been shown to be involved in the degradation of enkephalins in the mammalian brain and the inactivation of circulating atrial natriuretic peptide (1, 2). NEP has also been identified as the common acute lymphocytic leukemia antigen (CALLA), and is expressed on the surface of lymphocytes in some disease states (3, 4). These and other observations have resulted in considerable interest in NEP as a target for analgesics and antihypertensive drugs. NEP is also a major degrading enzyme of amyloid beta  peptide (A beta ) in the brain, indicating that down-regulation of NEP activity, which could be caused by aging, can contribute to the development of Alzheimer’s disease by promoting A beta accumulation (5).

Product Datasheets

Related Research Areas

• Acute Lymphoblastic Leukemia
• B Cell Markers
• Hematopoietic Progenitor Cell Markers
• Leukocyte Receptors/Markers in Tfh Cell Differentiation and Function
• Lymphoid Lineage Markers
• Metalloproteases and Regulators
• Neutrophils
• Proteolytic Degradation of Amyloid beta
• Renal Markers
• Renin-Angiotensin System
• Search Bioprocessing Enzymes
• T Cell Migration/Adhesion
• Vasoactive Peptide Hormones and Regulators