Human NGFR/TNFRSF16 Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: NGFR/TNFRSF16

p75 neurotrophin receptor, also named low affinity NGF receptor (NGF R), is a type I transmembrane protein that belongs to the tumor necrosis factor receptor family. NGF R cDNA encodes a 427 amino acid (aa) residue precursor protein with a 28 aa residue signal peptide, a 222 aa residue extracellular domain, a 22 aa residue transmembrane domain and a 155 aa residue intracellular domain. The extracellular region contains four cysteine-rich domains and binds NGF, BDNF, NT-3 and NT-4 approximately equally with low affinity. The cytoplasmic region contains a subtype 2 death domain.

NGF R expression has been shown to occur widely during development and in the adult. Expression has been detected in both neuronal and non-neuronal cells. NGF R was originally reported to function as a positive regulator of TrkA activity. NGF R has also been shown to signal by itself. Depending on its cellular environment, NGF R has now been shown to regulate cell migration, gene expression and to mediate apoptosis. Recombinant NGF R/Fc chimera binds NGF with high affinity and is a potent NGF antagonist. Naturally occurring truncated NGF R containing the extracellular domain and lacking the transmembrane or intracellular domain has been detected in vivo in urine, plasma and in amniotic fluid of humans and rats.

Product Datasheets

Related Research Areas

• Airway Inflammation and Remodeling
• Cancer Biomarkers
• Cancer Stem Cell Markers
• Cytokine and Growth Factor Receptors on VSMC
• Diabetes
• Glial Lineage Markers
• Mesenchymal Stem Cell Markers
• Microglia Homeostasis
• Neural Crest Cell Markers
• Neurotrophin/Trk Family
• Nogo Proteins and Receptors
• Receptor Tyrosine Kinases (RTKs)
• Regulation of Apoptosis by TNF Superfamily Members
• TNF Superfamily
• TNF Superfamily Receptors
• VPS10P-domain Family