Mouse Cyr61/CCN1 Antibody

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Cyr61/CCN1 in Mouse Trigeminal Ganglia.
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Product Details
Citations (1)
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Reviews (2)

Mouse Cyr61/CCN1 Antibody Summary

Species Reactivity
Detects mouse Cyr61/CCN1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Cyr61 is observed.
Monoclonal Rat IgG2B Clone # 466305
Protein A or G purified from hybridoma culture supernatant
E. coli-derived recombinant mouse Cyr61/CCN1
Accession # P18406
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
8-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry Cyr61/CCN1 antibody in Mouse Trigeminal Ganglia by Immunohistochemistry (IHC-Fr). View Larger

Cyr61/CCN1 in Mouse Trigeminal Ganglia. Cyr61/CCN1 was detected in perfusion fixed frozen sections of mouse trigeminal ganglia using 25 µg/mL Rat Anti-Mouse Cyr61/CCN1 Monoclonal Antibody (Catalog # MAB4864) overnight at 4 °C. Tissue was stained with the Anti-Rat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS017) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Cyr61/CCN1

Cyr61, also known as IGFBP-10 and CCN1, is a 50 kDa secreted matrix- and cell-associated glycoprotein that regulates the growth and adhesion of vascular endothelial cells, fibroblasts, and monocytes. Cyr61 interacts with cells that express integrins  alpha V beta 3, alpha V beta 5, alpha M beta 2, and alpha 6 beta 1. Cyr61 is cleaved by plasmin within its VWF domain which generates an N-terminal fragment that is not associated with the matrix but retains the ability to induce endothelial cell migration. Cyr61 induces VEGF upregulation, angiogenesis, and tumorigenesis. Between amino acids 176-281, mouse Cyr61 shares 87% and 97% amino acid sequence identity with human and rat Cyr61, respectively.

Long Name
Cysteine-Rich, Angiogenic Inducer 61
Entrez Gene IDs
3491 (Human); 16007 (Mouse); 83476 (Rat)
Alternate Names
CCN family member 1; CCN1; CCN1IGF-binding protein 10; Cyr61; Cysteine-rich angiogenic inducer 61; cysteine-rich, angiogenic inducer, 61; GIG1; GIG1cysteine-rich heparin-binding protein 61; IBP-10; IGFBP-10; IGFBP10cysteine-rich, anigogenic inducer, 61; Insulin-like growth factor-binding protein 10; protein CYR61; Protein GIG1

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Citation for Mouse Cyr61/CCN1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Plasminogen regulates mesenchymal stem cell-mediated tissue repair after ischemia through Cyr61 activation
    Authors: H Duan, Z He, M Lin, Y Wang, F Yang, RA Mitteer, HJ Kim, E Yeo, H Han, L Qin, Y Fan, Y Gong
    JCI Insight, 2020-08-06;5(15):.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Cells
    Applications: Functional Assay, Neutralization, Western Blot


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Mouse Cyr61/CCN1 Antibody
By Anonymous on 05/20/2019
Application: IP Sample Tested: C3H10T1/2 mouse embryonic fibroblast cell line Species: Mouse

Mouse Cyr61/CCN1 Antibody
By Anonymous on 07/15/2018
Application: ICC/IF Sample Tested: NIH-3T3 mouse embryonic fibroblast cell line Species: Mouse