11 results for "DREADD Activators Small Molecules and Peptides" in 产品
DREADD Activators Small Molecules and Peptides
DREADD Mechanism of Action
The first DREADDs to be developed were derived from human muscarinic acetylcholine receptors (mAChRs) and termed hM1-5. These receptors have mutations in their orthosteric binding site, abolishing their affinity for the endogenous ligand ACh, while rendering them responsive to small molecule DREADD ligands, such as Clozapine-N-oxide (CNO, Cat. No. 4936) or Deschloroclozapine (DCZ, Cat. No. 7193).
The effect of ligand binding depends on the G protein-coupling of the ...
Activator of hM3Dq and hM4Di DREADDs
| Alternate Names: | CNO |
| Chemical Name: | 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine |
| Purity: | ≥98% |
Activator of hM3Dq and hM4Di DREADDs; water soluble version of Clozapine N-oxide (Cat. No. 4936)
| Alternate Names: | CNO (water-soluble) |
| Chemical Name: | 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride |
| Purity: | ≥99% |
High affinity and highly potent activator of hM3Dq and hM4Di DREADDs; rapid blood-brain barrier penetrant
| Alternate Names: | DCZ |
| Chemical Name: | 11-(4-Methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine |
| Purity: | ≥98% |
Potent hM3Dq and hM4Di DREADD agonist; water soluble version of DREADD agonist 21 (Cat. No. 5548)
| Alternate Names: | Compound 21 (water-soluble) |
| Chemical Name: | 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride |
| Purity: | ≥98% |
Activator of κ-opioid DREADD (KORD)
| Chemical Name: | (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester |
| Purity: | ≥98% |
High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
| Chemical Name: | 8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5H-dibenzo[b,e][1,4]diazepine |
| Purity: | ≥98% |
Potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
| Alternate Names: | Compound 21,C21 |
| Chemical Name: | 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine |
| Purity: | ≥98% |
5-HT2A antagonist; also D2 antagonist; atypical antipsychotic
| Chemical Name: | 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine |
| Purity: | ≥98% |
Potent hM3Dq and hM4Di DREADD agonist in vitro
| Chemical Name: | 6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine |
| Purity: | ≥99% |
High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
| Chemical Name: | 8-Chloro-11-(4-ethylpiperazin-1-yl)-1-fluoro-5H-dibenzo[b,e][1,4]diazepine |
| Purity: | ≥98% |
Selective orthostatic agonist of hFFA2-DREADDs
| Chemical Name: | 4-Methoxy-3-methylbenzoic acid |
| Purity: | ≥98% |
