Metabolite of clozapine
(Cat. No. 0444). Activates human muscarinic designer receptors (DREADDs). Silences hippocampal neurons expressing hM4
DREADDs in vitro
. Suppresses food intake in hyperphagic mice with hM3
Dq-expressing, LMO4-deficient, paraventricular hypothalamic neurons.
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All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
- This product contains 1 molar equivalent of ethanol.
The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine.
Eiermann et al.
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.
Armbruster et al.
LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia.
Zaman et al.
The citations listed below are publications that use Tocris products. Selected citations for Clozapine N-oxide include:
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