Clozapine N-oxide

  ( 13 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:4936
Chemical Name:8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Product Details
Citations (13)
Supplemental Products
Reviews
Biological Activity
Metabolite of clozapine. Activates human muscarinic designer receptors (DREADDs) in vitro. Silences hippocampal neurons expressing hM4 DREADDs in vitro. Activates Gs-linked DREADDS- AgRP in mice via intracerebroventricular (i.c.v) injection. Shown to be a P-glycoprotein (P-gp) efflux pump substrate. Other potent and selective hM3Dq DREADD agonists available: DREADD agonist 21 and Perlapine.

Water soluble salt also available.

This product contains 1 molar equivalent of ethanol.

Technical Data
  • M.Wt:
    342.82
  • Formula:
    C18H19ClN4O
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    34233-69-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Clozapine N-oxide include:

13 Citations: Showing 1 - 10
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  1. Cholinergic neurons in medial septum maintain anxiety-like behaviors induced by chronic inflammatory pain.
    Authors: Jiang Et al.
    Neurosci Letts  2018;671:7
  2. Kisspeptin neurones in the posterodorsal medial amygdala modulate sexual partner preference and anxiety in male mice.
    Authors: Adekunbi Et al.
    J Neuroendocrinol  2018;30:e12572
  3. Glutamatergic projections from the entorhinal cortex to dorsal dentate gyrus mediate context-induced reinstatement of heroin seeking.
    Authors: Ge Et al.
    Neuropsychopharmacology  2017;42:1860
  4. A tale of two circuits: CCKNTS neuron stimulation controls appetite and induces opposing motivational states by projections to distinct brain regions.
    Authors: Roman Et al.
    Neuroscience  2017;358:316
  5. Cortico-accumbens regulation of approach-avoidance behavior Is modified by experience and chronic pain.
    Authors: Schwartz Et al.
    Cell Rep  2017;19:1522
  6. Inhibiting medial septal cholinergic neurons with DREADD alleviated anxiety-like behaviors in mice.
    Authors: Zhang Et al.
    Neurosci Letts  2017;18:139
  7. Visuomotor coupling shapes the functional development of mouse visual cortex.
    Authors: Attinger
    Cell  2017;169(7):1291
  8. Ethanol-seeking behavior is expressed directly through an extended amygdala to midbrain neural circuit.
    Authors: Pina and Cunningham Et al.
    Neurobiol Learn Mem  2017;137:83
  9. Using c-kit to genetically target cerebellar molecular layer interneurons in adult mice.
    Authors: Amat
    PLoS One  2017;12(6):e0179347
  10. Histamine modulation of the basal ganglia circuitry in the development of pathological grooming.
    Authors: Rapanelli
    Proc Natl Acad Sci U S A.  2017;114(25):6599
  11. Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit.
    Authors: D'Agostino Et al.
    PLoS Biol  2016;5
  12. Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity.
    Authors: Yuan and Grutzendler
    J Neurosci  2016;36:632
  13. Ethanol-seeking behavior is expressed directly through an extended amygdala to midbrain neural circuit.
    Authors: Pina and Cunningham
    Neurobiol Learn Mem  2016;137:83
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Average Rating: 4.6 (Based on 7 reviews)

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We have 7 reviews tested in 2 species: Mouse, Rat.

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  Excellent
  Mouse Anonymous 01/04/2018
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Species Mouse
  Excellent
  Mouse Anonymous 12/15/2017
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Species Mouse

Other Experimental Details

Other Experimental Details Product provides publishable work, no issues arose when dealing with the substance.
  Very Good
  Rat Anonymous 12/01/2017
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Species Rat
 CNO for chronic DREADD activation 4936 Array 4936
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Excellent
  Mouse Anonymous 12/01/2017
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 CNO for chronic DREADD activation 4936
: CNO for chronic DREADD activation [4936].

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Species Mouse

Other Experimental Details

Other Experimental Details Added saccharine to counteract bitter taste of DMSO used to dissolve CNO
  Excellent
  Rat Anonymous 10/20/2017
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Species Rat
  Very Good
  Mouse Anonymous 09/07/2017
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Species Mouse
  Very Good
  Mouse Anonymous 07/17/2017
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