Catalog Number: 4936
Chemical Name: 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Biological Activity
Metabolite of clozapine (Cat. No. 0444). Activates human muscarinic designer receptors (DREADDs). Silences hippocampal neurons expressing hM4 DREADDs in vitro. Suppresses food intake in hyperphagic mice with hM3Dq-expressing, LMO4-deficient, paraventricular hypothalamic neurons.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO and to 20 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
  • This product contains 1 molar equivalent of ethanol.
Background References
  1. The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine.
    Eiermann et al.
    Br.J.Clin.Pharmacol., 1997;44:439
  2. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.
    Armbruster et al.
    Proc.Natl.Acad.Sci.U.S.A., 2007;104:5163
  3. LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia.
    Zaman et al.
    J.Neurosci., 2014;34:140

The citations listed below are publications that use Tocris products. Selected citations for Clozapine N-oxide include:

Showing Results 1 - 1 of 1

  1. Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit.
    Authors: D'Agostino Et al.
    PLoS Biol
Tocris Small Molecules
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