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225 results for "FKBP12" in 产品

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FKBP12 Products

FK506 binding protein, also called FKBP12 and FKBP1A, was originally characterized as a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans-proline residues critical for proper folding of proteins. The macrolide immunosuppressants FK506 (Tacrolimus) and rapamycin bind to FKBP12 with high affinity, while the structurally related-compound cyclosporine binds with a much lower affinity. The binding of these drugs causes FKBP12 to become a potent inhibitor of calcineurin phosphatase activity and TOR kinase activity. Knockout mice lacking FKBP12 are morphologically normal, but develop cardiomyopathies that may be related to dysregulation of ryanodyne receptors.

Human/Mouse/Rat FKBP12 Antibody

Catalog #: MAB3777
(1)
Citations (4)
Product Documents
Reactivity: Human, Mouse, Rat
Details: Rat IgG2B Monoclonal Clone #422513
Applications: WB
Detection of Human/Mouse/Rat FKBP12 antibody by Western Blot.
(9)

dTAG-13

Catalog #: 6605
(4)
Citations (127)
Product Documents

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Chemical Name: 1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester
Purity: ≥98%
Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Everolimus

Catalog #: 6188
Citations (16)
Product Documents

mTOR inhibitor; Immunosuppressant

Alternate Names: RAD001
Chemical Name: 42-O-(2-Hydroxyethyl)rapamycin
Purity: ≥98%
mTOR inhibitor; Immunosuppressant

Human/Mouse/Rat FKBP12/FKBP12.6 Antibody

Catalog #: MAB4174
(1)
Product Documents
Reactivity: Human, Mouse, Rat
Details: Rat IgG2B Monoclonal Clone #426227
Applications: IHC, WB
Detection of Human, Mouse, and Rat FKBP12 and FKBP12.6 antibody by Western Blot.
(3)

FK 506

Catalog #: 3631
(2)
Citations (142)
Product Documents

Potent calcineurin inhibitor; immunosuppressant

Alternate Names: Tacrolimus,Fujimycin
Chemical Name: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone
Purity: ≥98%
Potent calcineurin inhibitor; immunosuppressant

Human FKBP12 Antibody

Catalog #: MAB37771
Product Documents
Reactivity: Human
Details: Mouse IgG2B Monoclonal Clone #1049713
Applications: WB, ICC/IF
(3)

FKBP12 Antibody

Catalog #: NB300-508
Citations (2)
Product Documents
Reactivity: Human, Mouse
Details: Rabbit IgG Polyclonal
Applications: IHC, WB, IP
Western Blot: FKBP12 Antibody [NB300-508]
(4)

FKBP12 Antibody (OTI3B3)

Catalog #: NBP2-02093
Product Documents
Reactivity: Human, Mouse, Rat
Details: Mouse IgG2B Monoclonal Clone #OTI3B3
Applications: IHC, WB, Flow
Western Blot: FKBP12 Antibody (OTI3B3) [NBP2-02093]
(4)

FKBP12 Antibody (OTI3B3) - Azide and BSA Free

Catalog #: NBP2-70741
Product Documents
Reactivity: Human, Mouse, Rat
Details: Mouse IgG2B Monoclonal Clone #OTI3B3
Applications: IHC, WB, Flow, CyTOF-ready
Western Blot: FKBP12 Antibody (OTI3B3)Azide and BSA Free [NBP2-70741]
(4)

FKBP12 Antibody (1E5-A12) - Azide and BSA Free

Catalog #: H00002280-M01
Citations (2)
Product Documents
Reactivity: Human
Details: Mouse IgG1 kappa Monoclonal Clone #1E5-A12
Applications: WB, ELISA, Func
Western Blot: FKBP12 Antibody (1E5-A12) [H00002280-M01]
(3)

dTAG-7

Catalog #: 6912
Citations (10)
Product Documents

First generation Degrader for mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Chemical Name: (1R)-3-(3,4-Dimethoxyphenyl)-1-(2-((19-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2,18-dioxo-7,10,13-trioxa-3,17-diazanonadecyl)oxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥98%
First generation Degrader for mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

FKBP12 Antibody - BSA Free

Catalog #: NBP2-41272
Product Documents
Reactivity: Human, Mouse, Rat
Details: Rabbit IgG Polyclonal
Applications: WB, ELISA, ICC/IF
Western Blot: FKBP12 AntibodyBSA Free [NBP2-41272]
(3)

Recombinant Human FKBP12 Protein, CF

Catalog #: 3777-FK
Citations (2)
Product Documents
Reactivity: Human
Source: E. coli
Accession #: NP_000792
Applications: Inhibition Activity
R&D Systems Recombinant Proteins and Enzymes

FKBP12 Antibody (E3) - BSA Free

Catalog #: NBP3-41645
Product Documents
Reactivity: Human, Porcine
Details: Mouse IgG2b Kappa Monoclonal Clone #E3
Applications: IHC, WB
FKBP12 Antibody (E3)
(3)

FKBP12 Antibody - BSA Free

Catalog #: NBP2-14017
Product Documents
Reactivity: Human
Details: Rabbit IgG Polyclonal
Applications: IHC, WB
Western Blot: FKBP12 Antibody [NBP2-14017]
(2)

AP 1867

Catalog #: 6207
Product Documents

Selective binding ligand for FKBP12F36V

Chemical Name: (1R)-1-[3-(Carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl (2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate
Purity: ≥98%
Selective binding ligand for FKBP12F36V

Ortho AP 1867

Catalog #: 7787
Product Documents

Selective binding ligand for FKBP12F36V; precursor for dTAG compounds

Chemical Name: 2-(2-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid
Purity: ≥98%
Selective binding ligand for FKBP12F36V; precursor for dTAG compounds

dTAG-Biotin

Catalog #: 7883
Product Documents

Affinity probe for mutant FKBP12F36V proteins

Chemical Name: (R)-3-(3,4-Dimethoxyphenyl)-1-(2-((2,16-dioxo-20-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-6,9,12-trioxa-3,15-diazaicosyl)oxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥98%
Affinity probe for mutant FKBP12F36V proteins

dTAG-Fluorescein

Catalog #: 7892
Product Documents

Fluorescent probe for labeling mutant FKBP12 (F36V) proteins

Chemical Name: (R)-1-(2-(2-((3',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)amino)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥95%
Fluorescent probe for labeling mutant FKBP12F36V proteins

dTAG Janelia Fluor® 635

Catalog #: 8101
Product Documents

Fluorogenic srTAG probe for live cell imaging of FBKP12 (F36V/L) fusion proteins

Chemical Name: 4-((2-(2-(3-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetamido)ethyl)carbamoyl)-2-(3-(3-fluoroazetidin-1-ium-1-ylidene)-7-(3-fluoroazetidin-1-yl)-5,5-dimethyl-3,5-dihydrodibenzo[b,e]silin-10-yl)benzoate
Purity: ≥95%
Fluorescent microscopy data of dTAG Janelia Fluor® 635 in HEK293 cells
(3)

dTAG Janelia Fluor® 525

Catalog #: 8102
Product Documents

Fluorogenic srTAG probe for live cell imaging of FBKP12 (F36V/L) fusion proteins

Chemical Name: 2-(3-(3,3-Difluoroazetidin-1-ium-1-ylidene)-6-(3,3-difluoroazetidin-1-yl)-3H-xanthen-9-yl)-4-((2-(2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetamido)ethyl)carbamoyl)benzoate
Purity: ≥95%
Fluorogenic srTAG probe for live cell imaging of FBKP12 (F36V/L) labelled proteins

dTAG Janelia Fluor® 585

Catalog #: 8103
Product Documents

Fluorogenic srTAG probe for live cell imaging of FKBP12(F36V/L) fusion proteins

Chemical Name: 2-(3-(3,3-Difluoroazetidin-1-ium-1-ylidene)-6-(3,3-difluoroazetidin-1-yl)-10,10-dimethyl-3,10-dihydroanthracen-9-yl)-4-((2-(2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetamido)ethyl)carbamoyl)benzoate
Purity: ≥95%
Fluorogenic srTAG probe for live cell imaging of FBKP12 (F36V/L) labelled proteins

TRAM 1

Catalog #: 8121
Citations (1)
Product Documents

Chemical inducer of proximity for dTAG protein FKBPF36V and ecDHFR tags

Chemical Name: (R)-1-(3-(2-((3-(4-((2,4-Diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)amino)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥98%
Chemical inducer of proximity for dTAG protein FKBPF36V and ecDHFR tags

Human/Mouse/Rat FKBP12/FKBP12.6 Alexa Fluor® 488‑conjugated Antibody

Catalog #: FAB4174G
Product Documents
Reactivity: Human, Mouse, Rat
Details: Rat IgG2B Monoclonal Clone #426227
Applications: IHC, WB
Human/Mouse/Rat FKBP12/FKBP12.6 Alexa Fluor® 488‑conjugated Antibody

Human/Mouse/Rat FKBP12/FKBP12.6 Alexa Fluor® 700‑conjugated Antibody

Catalog #: FAB4174N
Product Documents
Reactivity: Human, Mouse, Rat
Details: Rat IgG2B Monoclonal Clone #426227
Applications: IHC, WB
Human/Mouse/Rat FKBP12/FKBP12.6 Alexa Fluor® 700‑conjugated Antibody
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