Catalog Number: 4027
Chemical Name: (5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oic acid
Biological Activity
Synthetic derivative of prostaglandin E2 (Cat. No. 2296). Increases embryonic stem cell (ESC) hematopoietic colony formation in mouse bone marrow. Also induces an increase in hematopoietic stem cell (HSC) numbers and enhances Wnt activity within the HSC population in zebrafish embryos.
Technical Data
  • M.Wt:
    380.52
  • Formula:
    C22H36O5
  • Solubility:
    Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)
  • Purity:
    >98%
  • Storage:
    Store at -80°C
  • CAS No:
    39746-25-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Prostaglandin E2: making more of your marrow.
    Lord et al.
    Cell Cycle, 2007;6:3054
  2. Genetic interaction of PGE2 and wnt signaling regulates developmental specification of stem cells and regeneration.
    Goessling et al.
    Cell, 2009;136:1136
  3. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.
    North et al.
    , 2007;447:1007
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 16,16-Dimethyl Prostaglandin E2 include:

1 Citations: Showing 1 - 1

  1. Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization.
    Authors: Jansen Et al.
    Oncotarget 2015;19:210
Tocris Small Molecules
Description Application Cat# Citations Images  

Prostaglandin E2

2296 7  
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