16,16-Dimethyl Prostaglandin E2
Chemical Name: (5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oic acid
Biological ActivitySynthetic derivative of prostaglandin E2 (Cat. No. 2296). Increases embryonic stem cell (ESC) hematopoietic colony formation in mouse bone marrow. Also induces an increase in hematopoietic stem cell (HSC) numbers and enhances Wnt activity within the HSC population in zebrafish embryos.
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Prostaglandin E2 increases lentiviral vector transduction efficiency of adult human hematopoietic stem and progenitor cells.
Heffner et al.
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.
North et al.
Prostaglandin E2: making more of your marrow.
Lord et al.
Cell Cycle., 2007;6:3054
Genetic interaction of PGE2 and wnt signaling regulates developmental specification of stem cells and regeneration.
Goessling et al.
Citation for 16,16-Dimethyl Prostaglandin E2
The citations listed below are publications that use Tocris products. Selected citations for 16,16-Dimethyl Prostaglandin E2 include:
1 Citation: Showing 1 - 1
Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization.
Authors: Jansen Et al.
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