Catalog Number: 2206
Alternate Names: 2-Palm-Gl, 2-PG
Chemical Name: 2-Hydroxy-1-(hydroxymethyl)ethyl hexadecanoic acid ester
Biological Activity
Endogenous fatty acid glycerol ester that enhances activity of 2-arachidonylglycerol (Cat. No. 1298). Does not bind to CB1 or CB2 cannabinoid receptors, but potentiates the apparent binding of 2-AG and increases its ability to inhibit adenylyl cyclase. Enhances in vivo cannabinoid effects of 2-AG following combined administration with 2-linoleoylglycerol.
Technical Data
  • M.Wt:
    330.51
  • Formula:
    C19H38O4
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    23470-00-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Endocannabinoids and related fatty acid derivatives in pain modulation.
    Walker et al.
    Chem.Phys.Lipids, 2002;121:159
  2. An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonyl-glycerol cannabinoid activity.
    Ben-Shabat et al.
    Eur.J.Pharmacol., 1998;353:23
  3. 2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-α production in murine macrophages, and in mice.
    Gallily et al.
    Eur.J.Pharmacol., 2000;406:R5
Tocris Small Molecules
Description Application Cat# Citations Images  

2-Arachidonylglycerol

1298 12  
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