Endogenous fatty acid glycerol ester that enhances activity of 2-arachidonylglycerol
(Cat. No. 1298). Does not bind to CB1
cannabinoid receptors, but potentiates the apparent binding of 2-AG and increases its ability to inhibit adenylyl cyclase. Enhances in vivo
cannabinoid effects of 2-AG following combined administration with 2-linoleoylglycerol.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Endocannabinoids and related fatty acid derivatives in pain modulation.
Walker et al.
An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonyl-glycerol cannabinoid activity.
Ben-Shabat et al.
2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-α production in murine macrophages, and in mice.
Gallily et al.