5-BDBD

  ( 10 citations )    
Product Datasheet
Catalog Number:3579
Chemical Name:5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one
Product Details
Citations (10)
Supplemental Products
Reviews
Biological Activity
Potent P2X4 receptor antagonist. Blocks P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 0.50 μM).
Technical Data
  • M.Wt:
    355.19
  • Formula:
    C17H11BrN2O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    768404-03-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for 5-BDBD include:

10 Citations: Showing 1 - 10
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  1. Effect of P2X4R on airway inflammation and airway remodeling in allergic airway challenge in mice.
    Authors: Chen Et al.
    Mol Med Rep  2016;13:697
  2. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.
    Authors: Mascanfroni Et al.
    Circulation  2015;21:638
  3. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors.
    Authors: Kawano Et al.
    PLoS One  2015;10:e0127919
  4. A critical role for pannexin-1 in activation of innate immune cells of the choroid plexus.
    Authors: Maslieieva and Thompson
    Channels (Austin)  2014;8:131
  5. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
    Authors: Shabir Et al.
    Nat Med  2013;305:F396
  6. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
    Authors: Ilatovskaya Et al.
    Am J Physiol Cell Physiol  2013;305:C1050
  7. Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7.
    Authors: Vergani Et al.
    J Biol Chem  2013;127:463
  8. Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation.
    Authors: Trabanelli Et al.
    J Immunol  2012;189:1303
  9. Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors.
    Authors: Nörenberg Et al.
    Br J Pharmacol  2012;167:48
  10. Functional expression of P2X4 receptor in capillary endothelial cells of the cochlear spiral ligament and its role in regulating the capillary diameter.
    Authors: Wu Et al.
    Am J Physiol Heart Circ Physiol  2011;301:H69

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