Catalog # Availability Size / Price Qty
5-BDBD | CAS No. 768404-03-1 | P2X Receptor Antagonists
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Description: Potent and selective P2X4 antagonist

Chemical Name: 5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one

Purity: ≥99%

Product Details
Citations (18)
Supplemental Products

Biological Activity

5-BDBD is a potent and selective P2X4 receptor antagonist. Blocks P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 0.50 μM). Exhibits no significant antagonist effects at other P2X receptors. Reduces long-term potentiation (LTP) in rat hippocampal slices.

Technical Data

Soluble to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Cell-autonomous regulation of hematopoietic stem cell cycling activity by ATP.
    Casati et al.
    Cell Death Differ., 2011;18:396
  2. Painful purinergic receptors.
    Donnelly-Roberts et al.
    J.Pharmacol.Exp.Ther., 2008;324:409
  3. Characterization of the antagonist actions of 5-BDBD at the rat P2X4 receptor.
    Coddou et al.
    Neurosci Lett., 2018;

Product Datasheets

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Citations for 5-BDBD

The citations listed below are publications that use Tocris products. Selected citations for 5-BDBD include:

18 Citations: Showing 1 - 10

  1. Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance.
    Authors: Miguel Cruz & Beall
    Front Physiol  2020;11
  2. Ginsenosides Act As Positive Modulators of P2X4 Receptors.
    Authors: Dhuna Et al.
    Mol Pharmacol  2019;95:210
  3. Connexin-43-dependent ATP release mediates macrophage activation during sepsis.
    Authors: Dosch Et al.
    Elife  2019;8
  4. Intercellular Calcium Signaling Induced by ATP Potentiates Macrophage Phagocytosis.
    Authors: Zumerle Et al.
    Cell Rep  2019;27:1
  5. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.
    Authors: Uderhardt Et al.
    Cell  2019;177:541
  6. Relative Role of Akt, ERK and CREB in Alcohol-Induced Microglia P2X4R Receptor Expression.
    Authors: Gofman Et al.
    Alcohol Alcohol  2016;51:647
  7. Purinergic and store-operated Ca(2+) signaling mechanisms in mesenchymal stem cells and their roles in ATP-induced stimulation of cell migration.
    Authors: Peng Et al.
    Stem Cells  2016;34:2102
  8. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense.
    Authors: Ledderose Et al.
    J Infect Dis  2016;213:456
  9. Effect of P2X4R on airway inflammation and airway remodeling in allergic airway challenge in mice.
    Authors: Chen Et al.
    Mol Med Rep  2016;13:697
  10. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.
    Authors: Mascanfroni Et al.
    Circulation  2015;21:638


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