Catalog Number: 3579
Chemical Name: 5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one
Biological Activity
Potent P2X4 receptor antagonist. Blocks P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 0.50 μM).
Technical Data
  • M.Wt:
    355.19
  • Formula:
    C17H11BrN2O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    768404-03-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Painful purinergic receptors.
    Donnelly-Roberts et al.
    J.Pharmacol.Exp.Ther., 2008;324:409
  2. Cell-autonomous regulation of hematopoietic stem cell cycling activity by ATP.
    Casati et al.
    Cell Death Differ., 2011;18:396
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 5-BDBD include:

10 Citations: Showing 1 - 10
Filter your results:

  1. Effect of P2X4R on airway inflammation and airway remodeling in allergic airway challenge in mice.
    Authors: Chen Et al.
    Mol Med Rep 2016;13:697
  2. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.
    Authors: Mascanfroni Et al.
    Circulation 2015;21:638
  3. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors.
    Authors: Kawano Et al.
    PLoS One 2015;10:e0127919
  4. A critical role for pannexin-1 in activation of innate immune cells of the choroid plexus.
    Authors: Maslieieva and Thompson
    Channels (Austin) 2014;8:131
  5. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
    Authors: Shabir Et al.
    Nat Med 2013;305:F396
  6. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
    Authors: Ilatovskaya Et al.
    Am J Physiol Cell Physiol 2013;305:C1050
  7. Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7.
    Authors: Vergani Et al.
    J Biol Chem 2013;127:463
  8. Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation.
    Authors: Trabanelli Et al.
    J Immunol 2012;189:1303
  9. Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors.
    Authors: Nörenberg Et al.
    Br J Pharmacol 2012;167:48
  10. Functional expression of P2X4 receptor in capillary endothelial cells of the cochlear spiral ligament and its role in regulating the capillary diameter.
    Authors: Wu Et al.
    Am J Physiol Heart Circ Physiol 2011;301:H69

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