5-BDBD

Catalog # Availability Size / Price Qty
3579/10
3579/50
5-BDBD | CAS No. 768404-03-1 | P2X Receptor Antagonists
1 Image
Description: Potent and selective P2X4 antagonist

Chemical Name: 5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one

Purity: ≥99%

Product Details
Citations (16)
Supplemental Products
Reviews

Biological Activity

Potent and selective P2X4 receptor antagonist. Blocks P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 0.50 μM). Exhibits no significant antagonist effects at other P2X receptors. Reduces long-term potentiation (LTP) in rat hippocampal slices.

Technical Data

M.Wt:
355.19
Formula:
C17H11BrN2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
768404-03-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Cell-autonomous regulation of hematopoietic stem cell cycling activity by ATP.
    Casati et al.
    Cell Death Differ., 2011;18:396
  2. Painful purinergic receptors.
    Donnelly-Roberts et al.
    J.Pharmacol.Exp.Ther., 2008;324:409
  3. Characterization of the antagonist actions of 5-BDBD at the rat P2X4 receptor.
    Coddou et al.
    Neurosci Lett., 2018;

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Citations for 5-BDBD

The citations listed below are publications that use Tocris products. Selected citations for 5-BDBD include:

16 Citations: Showing 1 - 10

  1. Ginsenosides Act As Positive Modulators of P2X4 Receptors.
    Authors: Dhuna Et al.
    Mol Pharmacol  2019;95:210
  2. Connexin-43-dependent ATP release mediates macrophage activation during sepsis.
    Authors: Dosch Et al.
    Elife  2019;8
  3. Intercellular Calcium Signaling Induced by ATP Potentiates Macrophage Phagocytosis.
    Authors: Zumerle Et al.
    Cell Rep  2019;27:1
  4. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.
    Authors: Uderhardt Et al.
    Cell  2019;177:541
  5. Relative Role of Akt, ERK and CREB in Alcohol-Induced Microglia P2X4R Receptor Expression.
    Authors: Gofman Et al.
    Alcohol Alcohol  2016;51:647
  6. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense.
    Authors: Ledderose Et al.
    J Infect Dis  2016;213:456
  7. Effect of P2X4R on airway inflammation and airway remodeling in allergic airway challenge in mice.
    Authors: Chen Et al.
    Mol Med Rep  2016;13:697
  8. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.
    Authors: Mascanfroni Et al.
    Circulation  2015;21:638
  9. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors.
    Authors: Kawano Et al.
    PLoS One  2015;10:e0127919
  10. A critical role for pannexin-1 in activation of innate immune cells of the choroid plexus.
    Authors: Maslieieva and Thompson
    Channels (Austin)  2014;8:131

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