Catalog Number: 0901
Biological Activity
5-HT1B selective agonist, several times more potent than sumatriptan and inactive as a 5-HT1A agonist (Ki at 5-HT1B = 1 nM, selectivity over 5-HT1A > 300-fold). Mimics polysialic acid activity, stimulates neuritogenesis, myelination and Schwann cell migration in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 5-(Nonyloxy)tryptamine: a novel high affinity-5-HT1Dβ serotonin receptor agonist.
    Glennon et al.
    J.Med.Chem., 1994;37:2828
  2. Binding of O-Alkyl derivatives of serotonin at human 5-HT1Dβ receptors.
    Glennon et al.
    J.Med.Chem., 1996;39:314
  3. Nonyloxytryptamine mimics polysialic acid and modulates neuronal and glial functions in cell culture.
    Loers et al.
    J.Neurochem., 2013;128:88
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