( 16 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:3604
Chemical Name:(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
Product Details
Citations (16)
Biological Activity
Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor-β-activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF-κB (IC50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF-α-induced apoptosis in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO and to 10 mM in ethanol
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products. Selected citations for (5Z)-7-Oxozeaenol include:

16 Citations: Showing 1 - 10
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  1. Rapid Activation of Transforming Growth Factor β-Activated Kinase 1 in Chondrocytes by Phosphorylation and K(63) -Linked Polyubiquitination Upon Injury to Animal Articular Cartilage.
    Authors: Ismail Et al.
    Arthritis Rheumatol  2017;69:565
  2. MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.
    Authors: Jaco Et al.
    Mol Cell  2017;66:698
  3. TGFβ1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity.
    Authors: van Caam
    Arthritis Research & Therapy  2017;19(1):112
  4. Expression and function of transforming growth factor?β?activated protein kinase 1 in gastric cancer.
    Authors: Yang Et al.
    Mol Med Rep  2017;16:3103
  5. Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation.
    Authors: Jones Et al.
    Nat Chem Biol  2017;13:38
  6. Identification of therapeutic targets applicable to clinical strategies in ovarian cancer.
    Authors: Kim Et al.
    BMC Cancer  2016;16:678
  7. Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer.
    Authors: Huang Et al.
    Oncotarget  2015;6:995
  8. Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1β-stimulated C/EBP signaling pathway.
    Authors: Zhang Et al.
    Nat Commun  2015;35:778
  9. 5Z-7-Oxozeanol Inhibits the Effects of TGFβ1 on Human Gingival Fibroblasts.
    Authors: Kuk Et al.
    PLoS One  2015;10:e0123689
  10. BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo.
    Authors: Graham Et al.
    J Biol Chem  2014;5:5667
  11. Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules.
    Authors: Olsen Et al.
    Am J Respir Cell Mol Biol  2014;50:737
  12. Activation of TAK1 by MYD88 L265P drives malignant B-cell Growth in non-Hodgkin lymphoma.
    Authors: Ansell Et al.
    Blood Cancer J  2014;4:e183
  13. Prolonged NF-κB activation by a macrophage inhibitory cytokine 1-linked signal in enteropathogenic Escherichia coli-infected epithelial cells.
    Authors: Choi Et al.
    Infect Immun  2013;81:1860
  14. Protection from cerebral ischemia by inhibition of TGFβ-activated kinase.
    Authors: White Et al.
    Exp Neurol  2012;237:238
  15. The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.
    Authors: Ahmed Et al.
    Nat Immunol  2011;12:1176
  16. Phosphorylation of lysophosphatidylcholine acyltransferase 2 at Ser34 enhances platelet-activating factor production in endotoxin-stimulated macrophages.
    Authors: Morimoto Et al.
    Proc Natl Acad Sci U S A  2010;285:29857
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Species Mouse
Pub Med ID 25320283

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