Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor-β
-activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC50
= 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF-κ
= 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF-α
-induced apoptosis in vitro
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
A resorcyclic acid lactone, 5Z-7-Oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase.
Ninomiya-Tsuji et al.
Blockade of transforming growth factor-β-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade.
Choo et al.
Mol.Cancer Ther., 2006;5:2970
Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide.
Windheim et al.
The citations listed below are publications that use Tocris products. Selected citations for (5Z)-7-Oxozeaenol include:
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