(5Z)-7-Oxozeaenol

Tocris Bioscience | Catalog # 3604

Potent and selective TAK1 MAPKKK inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective TAK1 MAPKKK inhibitor
View all Other Kinase Inhibitors »

Product Description

(5Z)-7-Oxozeaenol is a resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor-β-activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF-κB (IC50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF-α-induced apoptosis in vitro.

Product Specifications for (5Z)-7-Oxozeaenol

Molecular Weight

362.37

Formula

C19H22O7

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione

CAS Number

253863-19-3

PubChem ID

9799061

InChI Key

NEQZWEXWOFPKOT-ULSULSEOSA-N

SMILES

O=C/2[C@@H](O)[C@@H](O)C/C=C/C1=CC(OC)=CC(O)=C1C(O[C@@H](C)C\C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.06 25

Preparing Stock Solutions for (5Z)-7-Oxozeaenol

The following data is based on the product molecular weight 362.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 11.04 mL 55.19 mL 110.38 mL
1.25 mM 2.21 mL 11.04 mL 22.08 mL
2.5 mM 1.10 mL 5.52 mL 11.04 mL
12.5 mM 0.22 mL 1.10 mL 2.21 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 116 publications citing the usage of this product.

Product Documents for (5Z)-7-Oxozeaenol

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (5Z)-7-Oxozeaenol

For research use only

Citations for (5Z)-7-Oxozeaenol

Customer Reviews for (5Z)-7-Oxozeaenol (2)

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  • Works for kinase assay, easy storage
    Name: Scott Scarneo
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 02/06/2019
    Works great for kinase assay. This was tested in TAK1 in vitro kinase assay.
    (5Z)-7-Oxozeaenol 3604
  • Great inhibitor for TAK1 signaling
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Primary human small airway epithelial cells
    Verified Customer | Posted 12/04/2017
    Primary human small airway epithelial cells were incubated with TAK1 inhibitor prior to the addition of poly(I:C). The supernatant was collected and analyzed for IL-6.
    (5Z)-7-Oxozeaenol 3604

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