Selective adenosine A2A
receptor antagonist and monoamine oxidase B (MAO-B) inhibitor (Ki
values are 54 and 28200 nM at rat A2A
receptors respectively and Ki
~ 100 nM at MAO-B). Potently protects against quinolinic acid
-induced (Cat. No. 0225) neuronal damage and is neuroprotective in the MPTP model of Parkinson's disease.
Soluble to 25 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions on monoamine oxidase inhibition and A2A receptor antagonism.
Chen et al.
Enhanced neuronal damage by co-administration of quinolinic acid and free radicals, and protection by adenosine A2A receptor antagonists.
Behan and Stone
Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC).
Vlok et al.
The citations listed below are publications that use Tocris products. Selected citations for 8-(3-Chlorostyryl)caffeine include:
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