8-(3-Chlorostyryl)caffeine

  ( 4 citations )    
Product Datasheet
Catalog Number:3306
Alternate Names:CSC
Chemical Name:(E)-8-[2-(3-Chlorophenyl)ethenyl]-3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity
Selective adenosine A2A receptor antagonist and monoamine oxidase B (MAO-B) inhibitor (Ki values are 54 and 28200 nM at rat A2A and A1 receptors respectively and Ki ~ 100 nM at MAO-B). Potently protects against quinolinic acid-induced (Cat. No. 0225) neuronal damage and is neuroprotective in the MPTP model of Parkinson's disease.
Technical Data
  • M.Wt:
    330.77
  • Formula:
    C16H15ClN4O2
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    147700-11-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 8-(3-Chlorostyryl)caffeine include:

4 Citations: Showing 1 - 4
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  1. Polo-like kinase 1 inhibits DNA damage response during mitosis.
    Authors: Benada Et al.
    Oncotarget  2015;14:219
  2. Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina.
    Authors: Li Et al.
    Vis Neurosci  2014;31:237
  3. Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils.
    Authors: Bao Et al.
    J Biol Chem  2013;288:22650
  4. Adenosine regulation of alveolar fluid clearance.
    Authors: Factor Et al.
    Cell Cycle  2007;104:4083

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