8-(3-Chlorostyryl)caffeine

Key Product Details

Product Description

8-(3-Chlorostyryl)caffeine is a selective adenosine A_2A receptor antagonist and monoamine oxidase B (MAO-B) inhibitor (K_i values are 54 and 28200 nM at rat A_2A and A₁ receptors respectively and K_i ~ 100 nM at MAO-B). Potently protects against quinolinic acid-induced (Cat. No. 0225) neuronal damage and is neuroprotective in the MPTP model of Parkinson's disease.

Product Specifications for 8-(3-Chlorostyryl)caffeine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 8-(3-Chlorostyryl)caffeine

The following data is based on the product molecular weight 330.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	12.09 mL	60.46 mL	120.93 mL
1.25 mM	2.42 mL	12.09 mL	24.19 mL
2.5 mM	1.21 mL	6.05 mL	12.09 mL
12.5 mM	0.24 mL	1.21 mL	2.42 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 20 publications citing the usage of this product.

• Behan and Stone Enhanced neuronal damage by co-administration of quinolinic acid and free radicals, and protection by adenosine A_2A receptor antagonists. Br.J.Pharmacol. 2002 PMID: 11906956
• Vlok Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC). Bioorg.Med.Chem. 2006 PMID: 16442801
• Chen 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions on monoamine oxidase inhibition and A_2A receptor antagonism. J.Biol.Chem. 2002 PMID: 12130655

Product Documents for 8-(3-Chlorostyryl)caffeine