Catalog Number: 3306
Alternate Names: CSC
Chemical Name: (E)-8-[2-(3-Chlorophenyl)ethenyl]-3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Biological Activity
Selective adenosine A2A receptor antagonist and monoamine oxidase B (MAO-B) inhibitor (Ki values are 54 and 28200 nM at rat A2A and A1 receptors respectively and Ki ~ 100 nM at MAO-B). Potently protects against quinolinic acid-induced (Cat. No. 0225) neuronal damage and is neuroprotective in the MPTP model of Parkinson's disease.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions on monoamine oxidase inhibition and A2A receptor antagonism.
    Chen et al.
    J.Biol.Chem., 2002;277:36040
  2. Enhanced neuronal damage by co-administration of quinolinic acid and free radicals, and protection by adenosine A2A receptor antagonists.
    Behan and Stone
    Br.J.Pharmacol., 2002;135:1435
  3. Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC).
    Vlok et al.
    Bioorg.Med.Chem., 2006;14:3512

The citations listed below are publications that use Tocris products. Selected citations for 8-(3-Chlorostyryl)caffeine include:

3 Citations: Showing 1 - 3
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  1. Polo-like kinase 1 inhibits DNA damage response during mitosis.
    Authors: Benada Et al.
    Oncotarget 2015;14:219
  2. Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina.
    Authors: Li Et al.
    Vis Neurosci 2014;31:237
  3. Adenosine regulation of alveolar fluid clearance.
    Authors: Factor Et al.
    Cell Cycle 2007;104:4083

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