A 438079 hydrochloride

  ( 36 citations )    
Product Datasheet
Catalog Number:2972
Chemical Name:3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride
Product Details
Citations (36)
Supplemental Products
Reviews
Biological Activity
Competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). Devoid of activity at other P2 receptors (IC50 >> 10 μM). Possesses antinociceptive activity in models of neuropathic pain in vivo. Inhibits methamphetamine-induced microglial migration and phagocytosis in vitro.
Technical Data
  • M.Wt:
    342.61
  • Formula:
    C13H9Cl2N5.HCl
  • Solubility:
    Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    899431-18-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for A 438079 hydrochloride include:

36 Citations: Showing 1 - 10
Filter your results:

  1. Targeting the NLRP3 inflammasome to attenuate spinal cord injury in mice.
    Authors: Jiang
    J Neuroinflammation  2017;14(1):207
  2. Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP.
    Authors: Karmakar Et al.
    Nat.Commun.  2016;7:10555
  3. Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides
    Authors: Russo Et al.
    The Journal of Immunology  2016;197:1353
  4. Neuronal Release of Cytokine IL-3 Triggered by Mechanosensitive Autostimulation of the P2X7 Receptor Is Neuroprotective.
    Authors: Lim Et al.
    Front Cell Neurosci  2016;10:270
  5. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death.
    Authors: Draganov Et al.
    Autophagy  2015;5:16222
  6. P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy.
    Authors: Wang Et al.
    Cell Res  2015;25:674
  7. Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells.
    Authors: Braganhol Et al.
    Biochim Biophys Acta  2015;1852:120
  8. Selected ginsenosides of the protopanaxdiol series are novel positive allosteric modulators of P2X7 receptors.
    Authors: Helliwell Et al.
    Br J Pharmacol  2015;172:3326
  9. The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells.
    Authors: Giannuzzo Et al.
    J Neurosci  2015;14:203
  10. Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells.
    Authors: Kowal Et al.
    Mol Cancer  2015;13:28
  11. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90.
    Authors: Young Et al.
    J Cell Sci  2015;11:113
  12. Extracellular ATP does not induce P2X7 receptor-dependent responses in cultured renal- and liver-derived swine macrophages.
    Authors: Takenouchi Et al.
    Purinergic Signal  2014;4:62
  13. Tanshinone II A sulfonate, but not tanshinone II A, acts as potent negative allosteric modulator of the human purinergic receptor P2X7.
    Authors: Kaiser Et al.
    J Pharmacol Exp Ther  2014;350:531
  14. Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia.
    Authors: Ochi-Ishi Et al.
    Biochem Biophys Res Commun  2014;10:53
  15. Enhanced autophagy blocks angiogenesis via degradation of gastrin-releasing peptide in neuroblastoma cells.
    Authors: Kim Et al.
    Cell Commun Signal  2013;9:1579
  16. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
    Authors: Ilatovskaya Et al.
    Am J Physiol Cell Physiol  2013;305:C1050
  17. Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naive human CD4+ T lymphocytes.
    Authors: Foster Et al.
    J Immunol  2013;190:1551
  18. Natural compounds with P2X7 receptor-modulating properties.
    Authors: Fischer Et al.
    Purinergic Signal  2013;10:313
  19. ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation.
    Authors: Manohar Et al.
    J Leukoc Biol  2012;92:787
  20. P2X7 receptor activation mediates organic cation uptake into human myeloid leukaemic KG-1 cells.
    Authors: Gadeock Et al.
    Neurosci Lett  2012;8:669
  21. Involvement of connexin43 hemichannel in ATP release after γ-irradiation.
    Authors: Ohshima Et al.
    Mol Pain  2012;53:551
  22. Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages.
    Authors: Kawano Et al.
    Results Immunol  2012;420:102
  23. P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice.
    Authors: Hoque Et al.
    Am J Physiol Gastrointest Liver Physiol  2012;302:G1171
  24. P2X?-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells.
    Authors: Grol Et al.
    Am J Physiol Endocrinol Metab  2012;302:E561
  25. Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow.
    Authors: Li Et al.
    J Cell Physiol  2012;227:172
  26. ATP induces protein arginine deiminase 2-dependent citrullination in mast cells through the P2X7 purinergic receptor.
    Authors: Arandjelovic Et al.
    J Immunol  2012;189:4112
  27. Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors.
    Authors: Nörenberg Et al.
    Br J Pharmacol  2012;167:48
  28. Purinergic signaling induces cyclooxygenase-1-dependent prostanoid synthesis in microglia: roles in the outcome of excitotoxic brain injury.
    Authors: Anrather Et al.
    PLoS One  2011;6:e25916
  29. The P2X7-Egr pathway regulates nucleotide-dependent inflammatory gene expression in microglia.
    Authors: Friedle Et al.
    Glia  2011;59:1
  30. Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations.
    Authors: Nörenberg Et al.
    J Biol Chem  2011;286:11067
  31. Tissue-nonspecific alkaline phosphatase promotes axonal growth of hippocampal neurons.
    Authors: Díez-Zaera Et al.
    Mol Biol Cell  2011;22:1014
  32. P2X(7) receptor antagonists display agonist-like effects on cell signaling proteins.
    Authors: Hedden Et al.
    Biochim Biophys Acta  2011;1810:532
  33. Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptors.
    Authors: Woehrle Et al.
    J Leukoc Biol  2010;88:1181
  34. P2X7-dependent release of interleukin-1β and nociception in the spinal cord following lipopolysaccharide.
    Authors: Clark Et al.
    J Radiat Res  2010;30:573
  35. Involvement of SLC17A9-dependent vesicular exocytosis in the mechanism of ATP release during T cell activation.
    Authors: Tokunaga Et al.
    J Biol Chem  2010;285:17406
  36. Inhibition of the ATP-gated P2X7 receptor promotes axonal growth and branching in cultured hippocampal neurons.
    Authors: Díaz-Hernández Et al.
    Autophagy  2008;121:3717
Expand to show all Citations

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used A 438079 hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee