A 438079 hydrochloride

Key Product Details

Product Description

A 438079 hydrochloride is a competitive P2X₇ receptor antagonist (pIC₅₀ = 6.9 for the inhibition of Ca²⁺ influx in the human recombinant P2X₇ cell line). Devoid of activity at other P2 receptors (IC₅₀ > 10 μM). Possesses antinociceptive activity in models of neuropathic pain in vivo. Inhibits methamphetamine-induced microglial migration and phagocytosis in vitro.

Product Specifications for A 438079 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for A 438079 hydrochloride

The following data is based on the product molecular weight 342.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.92 mL	14.59 mL	29.19 mL
5 mM	0.58 mL	2.92 mL	5.84 mL
10 mM	0.29 mL	1.46 mL	2.92 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 54 publications citing the usage of this product.

• Fernandes Methamphetamine alters microglial immune function through P2X₇R signaling. J.Neuroinflammation. 2016 PMID: 27117066
• Donnelly-Roberts and Jarvis Discovery of P2X₇ receptor-selective antagonists offers new insights into P2X₇ receptor function and indicates a role in chronic pain states. Br.J.Pharmacol. 2007 PMID: 17471177
• McGaraughty P2X₇-related modulation of pathological nociception in rats. Neuroscience 2007 PMID: 17478048
• Nelson Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X₇ antagonists. J.Med.Chem. 2006 PMID: 16759108

Product Documents for A 438079 hydrochloride