receptor antagonist (pIC50
= 6.9 for the inhibition of Ca2+
influx in the human recombinant P2X7
cell line). Devoid of activity at other P2 receptors (IC50
>> 10 μ
M). Possesses antinociceptive activity in models of neuropathic pain in vivo
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All Tocris products are intended for laboratory research use only.
Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists.
Nelson et al.
Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states.
Donnelly-Roberts and Jarvis
P2X7-related modulation of pathological nociception in rats.
McGaraughty et al.
The citations listed below are publications that use Tocris products. Selected citations for A 438079 hydrochloride include:
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