Catalog Number: 3060
Chemical Name: 9-(Dimethylamino)-3-(hexahydro-1H-azepin-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one
Biological Activity
Potent, non-competitive mGlu1 receptor antagonist that displays 34-fold selectivity over mGlu5 (IC50 values are 10 and 342 nM respectively). Displays no significant activity at a range of other GPCRs, ion channels and transporters. Exhibits analgesic effects; decreases mechanical allodynia in models of neuropathic pain. Also impairs cognitive function.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists.
    Zheng et al.
    J.Med.Chem., 2005;48:7374
  2. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist.
    El-Kouhen et al.
    Br.J.Pharmacol., 2006;149:761
  3. Comparison of the mGluR1 antagonist A-841720 in rats models of pain and cognition.
    More et al.
    Behav.Pharmacol., 2007;18:273

The citations listed below are publications that use Tocris products. Selected citations for A 841720 include:

1 Citations: Showing 1 - 1

  1. Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation.
    Authors: Veettil Et al.
    PLoS Pathog 2014;10:e1004389

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    3060 has been discontinued.

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