A 841720

  ( 1 citations )    
Product Datasheet
Catalog Number:3060
Chemical Name:9-(Dimethylamino)-3-(hexahydro-1H-azepin-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one
Product Details
Citations (1)
Reviews
Biological Activity
Potent, non-competitive mGlu1 receptor antagonist that displays 34-fold selectivity over mGlu5 (IC50 values are 10 and 342 nM respectively). Displays no significant activity at a range of other GPCRs, ion channels and transporters. Exhibits analgesic effects; decreases mechanical allodynia in models of neuropathic pain. Also impairs cognitive function.
Technical Data
  • M.Wt:
    343.45
  • Formula:
    C17H21N5OS
  • Solubility:
    Soluble to 50 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    869802-58-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for A 841720 include:

1 Citations: Showing 1 - 1

  1. Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation.
    Authors: Veettil Et al.
    PLoS Pathog  2014;10:e1004389

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