Catalog Number: 3060
Chemical Name: 9-(Dimethylamino)-3-(hexahydro-1H-azepin-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one
Biological Activity
Potent, non-competitive mGlu1 receptor antagonist that displays 34-fold selectivity over mGlu5 (IC50 values are 10 and 342 nM respectively). Displays no significant activity at a range of other GPCRs, ion channels and transporters. Exhibits analgesic effects; decreases mechanical allodynia in models of neuropathic pain. Also impairs cognitive function.
Technical Data
  • M.Wt:
    343.45
  • Formula:
    C17H21N5OS
  • Solubility:
    Soluble to 50 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    869802-58-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists.
    Zheng et al.
    J.Med.Chem., 2005;48:7374
  2. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist.
    El-Kouhen et al.
    Br.J.Pharmacol., 2006;149:761
  3. Comparison of the mGluR1 antagonist A-841720 in rats models of pain and cognition.
    More et al.
    Behav.Pharmacol., 2007;18:273
Citations:

The citations listed below are publications that use Tocris products. Selected citations for A 841720 include:

1 Citations: Showing 1 - 1

  1. Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation.
    Authors: Veettil Et al.
    PLoS Pathog 2014;10:e1004389

Have you used A 841720?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

    3060 has been discontinued.

    Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information