A 841720

Name: A 841720
Brand: Tocris Bioscience
SKU: 3060

Catalog #: 3060
2 Citations Datasheet / COA / SDS

Discontinued Product

3060 has been discontinued.

View all Group I mGluR Antagonists products.

A 841720 | CAS No. 869802-58-4 | Group I mGluR Antagonists

1 Image

Description: Selective mGlu1 antagonist

Chemical Name: 9-(Dimethylamino)-3-(hexahydro-1H-azepin-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one

Purity: ≥98%

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Product Details

Citations (2)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Potent, non-competitive mGlu₁ receptor antagonist that displays 34-fold selectivity over mGlu₅ (IC₅₀ values are 10 and 342 nM respectively). Displays no significant activity at a range of other GPCRs, ion channels and transporters. Exhibits analgesic effects; decreases mechanical allodynia in models of neuropathic pain. Also impairs cognitive function.

Technical Data

M.Wt:

343.45

Formula:

C₁₇H₂₁N₅OS

Solubility:

Soluble to 50 mM in DMSO and to 50 mM in ethanol

Purity:

≥98%

Storage:

Store at RT

CAS No:

869802-58-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists.
Zheng et al.
J.Med.Chem., 2005;48:7374
Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist.
El-Kouhen et al.
Br.J.Pharmacol., 2006;149:761
Comparison of the mGluR1 antagonist A-841720 in rats models of pain and cognition.
More et al.
Behav.Pharmacol., 2007;18:273

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for A 841720

The citations listed below are publications that use Tocris products. Selected citations for A 841720 include:

2 Citations: Showing 1 - 2

Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation.
Authors: Veettil Et al.
PLoS Pathog 2014;10:e1004389
Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
Authors: Rojas Et al.
Mol Pharmacol 2013;83:106

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