Potent, non-competitive mGlu1
receptor antagonist that displays 34-fold selectivity over mGlu5
values are 10 and 342 nM respectively). Displays no significant activity at a range of other GPCRs, ion channels and transporters. Exhibits analgesic effects; decreases mechanical allodynia in models of neuropathic pain. Also impairs cognitive function.
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All Tocris products are intended for laboratory research use only.
Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists.
Zheng et al.
Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist.
El-Kouhen et al.
Comparison of the mGluR1 antagonist A-841720 in rats models of pain and cognition.
More et al.
The citations listed below are publications that use Tocris products. Selected citations for A 841720 include:
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