Highly potent and selective competitive antagonist for α
2 subunit-containing nicotinic receptors (IC50
= 0.5 - 3.5 nM at α
2 expressed in Xenopus oocytes). Also potently blocks β
3-containing neuronal nicotinic receptors. Displays > 200-fold selectivity for α
2 over α
2 and α
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Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes.
David et al.
A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors.
Cartier et al.
Conus peptides: novel probes for nicotinic acetylcholine receptor structure and function.
McIntosh et al.
Determinants of specificity for α-conotoxin MII on α3β2 neuronal nicotinic receptors.
Harvey et al.
The citations listed below are publications that use Tocris products. Selected citations for α-Conotoxin MII include:
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