Chemical Name: 1,2-Dithiolane-3-pentanoic acid
Biological Activity(±)-α-Lipoic acid is a liquid-liquid phase separated condensate modifier. Reduces stress granule formation in HeLa cells. Also stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of FUS mutant motor neurons in culture and reverses motor defects in D. melanogaster expressing mutated human FUS.
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Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway.
Shen et al.
The pharmacology of the antioxidant lipoic acid.
Biewenga et al.
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