ABS 205

Name: ABS 205
Brand: Tocris Bioscience
SKU: 2721

Catalog #: 2721 Datasheet / COA / SDS

Discontinued Product

2721 has been discontinued.

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ABS 205 | CAS No. 24102-11-2 | Cell Adhesion Inhibitors

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Description: Upregulates NCAM expression. Valproic acid (Cat. No. 2815) derivative

Alternative Names: 4-yn-VPA

Chemical Name: 2-Propyl-4-pentynoic acid

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Biological Activity

Orally active valproic acid (Cat No. 2815) derivative that exhibits teratogenic and neuroprotective activity. Upregulates neural cell adhesion molecule (NCAM) expression, activates PPARδ (IC₅₀ = 0.6 mM) and increases Hoxa1 expression in rat embryos. Antiproliferative; induces G₁ cell cycle arrest in C6 glioma cells (IC₅₀ ~ 2 mM).

Technical Data

M.Wt:

140.18

Formula:

C₈H₁₂O₂

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Storage:

Store at +4°C

CAS No:

24102-11-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Cell proliferation, migration and CAM-dependent neurite outgrowth as developmental in vitro endpoints for screening teratogenic potential: application to valproic acid and related analogues of varying potency.
Bacon et al.
Toxicol.In Vitro, 1998;12:101
Modulation of peroxisome proliferator-activated receptor δ activity affects neural cell adhesion molecule and polysialyltransferase ST8SiaIV induction by teratogenic valproic acid analogs in F9 cell differentiation.
Lampen et al.
Mol.Pharmacol., 2005;68:193
Induction of the homeotic gene Hoxa1 through valproic acid's teratogenic mechanism of action.
Stodgell et al.
Neurotoxicol.Teratol., 2006;28:617

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