Catalog Number: 5038
Chemical Name: 1H-Benzotriazol-1-amine
Biological Activity
Cytochrome P450 inhibitor. Inhibits synthesis of the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE). Reduces intimal hyperplasia and vascular remodeling following endothelial injury in rat carotid arteries.
Technical Data
  • M.Wt:
    134.14
  • Formula:
    C6H6N4
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    1614-12-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole.
    Mathews et al.
    J.Pharmacol.Exp.Ther., 1985;235:186
  2. 20-hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries.
    Orozco et al.
    J.Pharmacol.Exp.Ther., 2013;346:67
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ABT include:

1 Citations: Showing 1 - 1

  1. Further evidence for the role of IP 3R 1 in regulating subsynaptic gene expression and neuromuscular transmission.
    Authors: Zhu and Gomez
    Pharmacol Res Perspect 2012;6:65

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