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AC 4

Catalog #: 5464 Datasheet / COA / SDS

Discontinued Product

5464 has been discontinued.
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AC 4 | CAS No. 1459809-09-6 | TRPV Antagonists
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Description: Photoswitchable TRPV1 channel blocker

Chemical Name: 1,3,4,5-Tetrahydro-7,8-dihydro-N-[2-[4-[2-[4-(trifluoromethyl)phenyl]diazenyl]phenyl]ethyl]-2H-2-benzazepine-2-carbothioamide

Purity: ≥98%

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Biological Activity

AC 4 is a photoswitchable TRPV1 channel blocker (IC50 = 3.1 μM). Acts as an antagonist in trans conformation during voltage gated activation. Also acts as an antagonist in the cis formation during capsaicin-induced TRPV1 currents. Switches conformation from cis to trans at 440 nm and trans to cis at 360 nm. Allows photoswitchable antagonist and an agonist to be applied at the same time.

Technical Data

M.Wt:
514.56
Formula:
C26H25F3N4O2S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in water with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1459809-09-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Optical control of TRPV1 channels.
    Stein et al.
    Angew.Chem.Int.Ed.Engl., 2013;52:9845

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