Photoswitchable TRPV1 channel blocker (IC50
= 3.1 μ
M). Acts as an antagonist in trans
conformation during voltage gated activation. Also acts as an antagonist in the cis
formation during capsaicin-induced TRPV1 currents. Switches conformation from cis
at 440 nm and trans
at 360 nm. Allows photoswitchable antagonist and an agonist to be applied at the same time.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Optical control of TRPV1 channels.
Stein et al.