Catalog Number: 1575
Chemical Name: N-Acetyl-Leu-Glu-His-Asp-(7-amino-4-trifluoromethylcoumarin)
Biological Activity
Fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC.
Technical Data
  • M.Wt:
    765.7
  • Formula:
    C33H38F3N7O11
  • Sequence:
    LEHD

    (Modifications: Leu-1 = N-Ac-Leu, Asp-4 = Asp-(7-amino-4-trifluoromethylcoumarin))

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    210345-03-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells.
    Ito et al.
    Biochim.Biophys.Acta, 1999;1452:263
  2. Mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cells.
    Moriya et al.
    FEBS Lett., 2000;484:253

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