ACDPP hydrochloride

Name: ACDPP hydrochloride
Brand: Tocris Bioscience
SKU: 2254

Catalog #: 2254 Datasheet / COA / SDS

Discontinued Product

2254 has been discontinued.

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ACDPP hydrochloride | Group I mGluR Antagonists

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Description: Selective mGlu5 antagonist

Chemical Name: 3-Amino-6-chloro-5-dimethylamino-N-2-pyridinylpyrazinecarboxamide hydrochloride

Purity: ≥99%

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Product Details

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Antagonist at the mGlu₅ receptor (K_i = 295 nM). Inhibits human mGlu₅ receptor-mediated calcium flux with an IC₅₀ of 134 nM.

Technical Data

M.Wt:

329.19

Formula:

C₁₂H₁₃ClN₆O.HCl

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥99%

Storage:

Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.
Bonnefous et al.
Bioorg.Med.Chem.Lett., 2005;15:1197
Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors.
Wang et al.
J.Neurosci., 2008;28:4385

Product Datasheets

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M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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