ACDPP hydrochloride (CAS 37804-11-8): R&D Systems
Catalog Number: 2254
Chemical Name: 3-Amino-6-chloro-5-dimethylamino-N-2-pyridinylpyrazinecarboxamide hydrochloride
Biological Activity
Antagonist at the mGlu5 receptor (Ki = 295 nM). Inhibits human mGlu5 receptor-mediated calcium flux with an IC50 of 134 nM.
Technical Data
  • M.Wt:
    329.19
  • Formula:
    C12H13ClN6O.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    37804-11-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.
    Bonnefous et al.
    Bioorg.Med.Chem.Lett., 2005;15:1197
  2. Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors.
    Wang et al.
    J.Neurosci., 2008;28:4385

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