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ACPA

Catalog #: 1318
12 Citations Datasheet / COA / SDS

Discontinued Product

1318 has been discontinued.
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ACPA | CAS No. 229021-64-1 | Cannabinoid R1/CB1 Agonists
1 Image
Description: Potent and selective CB1 agonist
Alternative Names: Arachidonylcyclopropylamide

Chemical Name: N-(Cyclopropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide

Product Details
Citations (12)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Potent and selective CB1 agonist (Ki = 2.2 nM). Displays 325-fold selectivity over CB2 receptors. Active in vivo.

Water Soluble Emulsion also available.

Technical Data

M.Wt:
343.55
Formula:
C23H37NO
Solubility:
Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
Storage:
Store at -20°C
CAS No:
229021-64-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Pharmacology of cannabinoid receptor ligands.
    Pertwee
    Curr.Med.Chem., 1999;6:635
  2. Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1).
    Hillard et al.
    J.Pharmacol.Exp.Ther., 1999;289:1427
  3. Cannabinoid CB1 receptor agonists produce cerebellar dysfunction in mice.
    Patel et al.
    2001 Symposium on the Cannabinoids, International, 2001;

Product Datasheets

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Citations for ACPA

The citations listed below are publications that use Tocris products. Selected citations for ACPA include:

12 Citations: Showing 1 - 10

  1. MRAP2 regulates ghrelin receptor signaling and hunger sensing.
    Authors: Srisai Et al.
    Nat Commun  2017;8:713
  2. The major neurotransmitter systems in the basolateral amygdala and the ventral tegmental areamediate morphine-induced memory consolidation impairment.
    Authors: Sharifi
    Neuroscience  2017;353:7
  3. Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation.
    Authors: Han
    Brain Res  2017;1663:132
  4. The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA.
    Authors: Kangarlu-Haghighi Et al.
    Br J Pharmacol  2015;14:613
  5. Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and "triptan" receptors: implications in migraine.
    Authors: Akerman Et al.
    J Neurosci  2013;33:14869
  6. Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats.
    Authors: Niu Et al.
    EXCLI J  2012;153:2283
  7. A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
    Authors: Buznikov Et al.
    Dev Neurosci  2010;32:1
  8. Evaluation of the role of striatal cannabinoid CB1 receptors on movement activity of parkinsonian rats induced by rese.
    Authors: Moghaddam Et al.
    Saudi Pharm J  2010;18:207
  9. Effects of cannabinoids on caffeine contractures in slow and fast skeletal muscle fibers of the frog.
    Authors: Huerta Et al.
    J Membr Biol  2009;229:91
  10. Modulation of network oscillatory activity and GABAergic synaptic transmission by CB1 cannabinoid receptors in the rat medial entorhinal cortex.
    Authors: Morgan Et al.
    Neural Plast  2008;2008:808564

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