Biological Activityα-Conotoxin AuIB is a selective antagonist of α3β4 nicotinic acetylcholine receptors. Displays > 100-fold selectivity over other receptor subunit combinations including α2β2, α2β4, α3β2, α4β2, α4β4 and α1β1γδ.
(Modifications: Cys-15 = C-terminal amide, Disulfide bridges: 2-8, 3-15)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
α-Conotoxin AuIB selectively blocks α3β4 nicotinic acetylcholine receptors and nicotine-evoked NE release.
Luo et al.
Relating neuronal nicotinic acetylcholine receptor subtypes defined by subunit composition and channel function.
Nai et al.
An α3β4 subunit combination acts as a major functional nicotinic acetylcholine receptor in male rat pelvic ganglion neurons.
Park et al.
Pflugers Arch., 2006;452:775
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