α-Conotoxin MII
Purity: ≥95%
Biological Activity
α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuronal nicotinic receptors. Displays > 200-fold selectivity for α3β2 over α2β2, α4β2 and α3β4.Technical Data
(Modifications: Disulfide bridges: 2-8, 3-16, Cys-16 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Additional Information
Background References
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A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors.
Cartier et al.
J.Biol.Chem., 1996;271:7522 -
Determinants of specificity for α-conotoxin MII on α3β2 neuronal nicotinic receptors.
Harvey et al.
Mol.Pharmacol., 1997;51:336 -
Conus peptides: novel probes for nicotinic acetylcholine receptor structure and function.
McIntosh et al.
Eur.J.Pharmacol., 2000;393:205 -
Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes.
David et al.
Eur.J.Neurosci., 2010;31:978
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Citation for α-Conotoxin MII
The citations listed below are publications that use Tocris products. Selected citations for α-Conotoxin MII include:
1 Citation: Showing 1 - 1
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CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression.
Authors: Krais Et al.
Carcinogenesis 2011;32:1388
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