Biological Activityα-Conotoxin PIA is a selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).
(Modifications: Cys-18 - C-terminal amide, Disulfide bridge between 4 - 10, 5 - 18)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
α-Conotoxin PIA is selective for α6 subunit-containing nicotinic acetylcholine receptors.
Dowell et al.
Effect of novel α-Conotoxins on nicotine-stimulated [3H]DA release from rat striatal synaptosomes.
Azam and McIntosh
Solution structure of α-conotoxin PIA, a novel antagonist of α6 subunit containing nicotinic acetylcholine receptors.
Chi et al.
Citation for α-Conotoxin PIA
The citations listed below are publications that use Tocris products. Selected citations for α-Conotoxin PIA include:
1 Citation: Showing 1 - 1
Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of DA release in the rat striatum.
Authors: Garção Et al.
Br J Pharmacol 2013;169:1600
No product specific FAQs exist for this product, however you mayView all Peptide FAQs
Reviews for α-Conotoxin PIA
There are currently no reviews for this product. Be the first to review α-Conotoxin PIA and earn rewards!
Have you used α-Conotoxin PIA?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image