α-Conotoxin PIA

Catalog # Availability Size / Price Qty
3121/500U
α-Conotoxin PIA
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Description: Selective antagonist of α6-containing nAChRs
Product Details
Citations (1)
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Reviews

Biological Activity

Selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).

Technical Data

M.Wt:
1981.3
Formula:
C79H125N27O25S4
Sequence:
RDPCCSNPVCTVHNPQIC

(Modifications: Cys-18 - C-terminal amide, Disulfide bridge between 4 - 10, 5 - 18)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
669050-68-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from University of Utah

Background References

  1. α-Conotoxin PIA is selective for α6 subunit-containing nicotinic acetylcholine receptors.
    Dowell et al.
    J.Neurosci., 2003;23:8445
  2. Effect of novel α-Conotoxins on nicotine-stimulated [3H]DA release from rat striatal synaptosomes.
    Azam and McIntosh
    J.Pharmacol.Exp.Ther., 2005;312:231
  3. Solution structure of α-conotoxin PIA, a novel antagonist of α6 subunit containing nicotinic acetylcholine receptors.
    Chi et al.
    Biochem.Biophys.Res.Comms., 2005;338:1990

Product Datasheets

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Citation for α-Conotoxin PIA

The citations listed below are publications that use Tocris products. Selected citations for α-Conotoxin PIA include:

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