α-Conotoxin PIA
Biological Activity
α-Conotoxin PIA is a selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).Technical Data
(Modifications: Cys-18 - C-terminal amide, Disulfide bridge between 4 - 10, 5 - 18)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Additional Information
Background References
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α-Conotoxin PIA is selective for α6 subunit-containing nicotinic acetylcholine receptors.
Dowell et al.
J.Neurosci., 2003;23:8445 -
Effect of novel α-Conotoxins on nicotine-stimulated [3H]DA release from rat striatal synaptosomes.
Azam and McIntosh
J.Pharmacol.Exp.Ther., 2005;312:231 -
Solution structure of α-conotoxin PIA, a novel antagonist of α6 subunit containing nicotinic acetylcholine receptors.
Chi et al.
Biochem.Biophys.Res.Comms., 2005;338:1990
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Citation for α-Conotoxin PIA
The citations listed below are publications that use Tocris products. Selected citations for α-Conotoxin PIA include:
1 Citation: Showing 1 - 1
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Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of DA release in the rat striatum.
Authors: Garção Et al.
Br J Pharmacol 2013;169:1600
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