Catalog Number: 3121
Biological Activity
Selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).
Technical Data
  • M.Wt:
    1981.3
  • Formula:
    C79H125N27O25S4
  • Sequence:
    RDPCCSNPVCTVHNPQIC

    (Modifications: Cys-18 - C-terminal amide, Disulfide bridge between 4 - 10, 5 - 18)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    669050-68-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from University of Utah
Background References
  1. α-Conotoxin PIA is selective for α6 subunit-containing nicotinic acetylcholine receptors.
    Dowell et al.
    J.Neurosci., 2003;23:8445
  2. Effect of novel α-Conotoxins on nicotine-stimulated [3H]Dopamine release from rat striatal synaptosomes.
    Azam and McIntosh
    J.Pharmacol.Exp.Ther., 2005;312:231
  3. Solution structure of α-conotoxin PIA, a novel antagonist of α6 subunit containing nicotinic acetylcholine receptors.
    Chi et al.
    Biochem.Biophys.Res.Comms., 2005;338:1990

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