α-Conotoxin PnIA (CAS 705300-84-1): R&D Systems
Catalog Number: 3123
Biological Activity
Selective antagonist of α3β2 nAChR receptors (IC50 values are 9.56 and 252 nM for α3β2 and α7 receptors respectively).
Technical Data
  • M.Wt:
    1622.82
  • Formula:
    C65H95N19O22S4
  • Sequence:
    GCCSLPPCAANNPDYC

    (Modifications: Cys-16 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 16)

  • Solubility:
    Soluble to 5 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    705300-84-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from University of Utah
Background References
  1. New mollusc-specific α-conotoxins block Aplysia neuronal acetylcholine receptors.
    Fainzilber et al.
    Biochemistry, 1994;33:9523
  2. Single-residue alteration in α-conotoxin PnIA switches its nAChR subtype selectivity.
    Luo et al.
    Biochemistry, 1999;38:14542
  3. Identification of residues that confer α-conotoxin-PnIA sensitivity on the α3 subunit of neuronal nicotinic acetylcholine receptors.
    Everhart et al.
    J.Pharmacol.Exp.Ther., 2003;306:664

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