α-Conotoxin PnIA
Tocris Bioscience | Catalog # 3123
Selective α3β2 nAChR antagonist
Discontinued Product
3123 has been discontinued.
View all Additional Nicotinic Receptor Antagonists products.
Key Product Details
Description
Selective α3β2 nAChR antagonist
Product Description
α-Conotoxin PnIA is a selective antagonist of α3β2 nAChR receptors (IC50 values are 9.56 and 252 nM for α3β2 and α7 receptors respectively).Licensing Information
Sold under license from University of Utah
Product Specifications for α-Conotoxin PnIA
Molecular Weight
1622.82
Formula
C65H95N19O22S4
Storage
Desiccate at -20°C
CAS Number
705300-84-1
PubChem ID
73755066
InChI Key
VUVGEYBNLLGGBG-MVPSLEAZSA-N
SMILES
[H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC2=O)C(N)=O)NC1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Solubility
| Solubility | Soluble to 5mg/ml in water |
Calculators
Background References
References are publications that support the biological activity of the product.
- Luo Single-residue alteration in α-conotoxin PnIA switches its nAChR subtype selectivity. Biochemistry 1999 PMID: 10545176
- Everhart Identification of residues that confer α-conotoxin-PnIA sensitivity on the α3 subunit of neuronal nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 2003 PMID: 12734390
- Fainzilber New mollusc-specific α-conotoxins block Aplysia neuronal acetylcholine receptors. Biochemistry 1994 PMID: 8068627
Product Documents for α-Conotoxin PnIA
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for α-Conotoxin PnIA
For research use only
Related Research Areas
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