α-Spinasterol

Tocris Bioscience | Catalog # 4729

TRPV1 antagonist; active in vivo
Tocris Bioscience
Discontinued Product
4729 has been discontinued. View all TRPV Antagonists products.

Key Product Details

Description

TRPV1 antagonist; active in vivo
View all TRPV Antagonists »

Product Description

α-Spinasterol is a TRPV1 antagonist (IC50 = 1.4 μM). Reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Brain penetrant and orally bioavailable.

Product Specifications for α-Spinasterol

Molecular Weight

412.69

Formula

C29H48O

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(3β,5α,22E)-Stigmasta-7.22-dien-3-ol

CAS Number

481-18-5

PubChem ID

5281331

InChI Key

JZVFJDZBLUFKCA-FXIAWGAOSA-N

SMILES

C[C@H](/C=C/[C@@H](CC)C(C)C)[C@@]4([H])CC[C@@]3([H])C2=CC[C@@]1([H])C[C@@H](O)CC[C@@](C)1[C@]([H])2CC[C@@]34C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Ethanol 4.13 10 with gentle warming

Preparing Stock Solutions for α-Spinasterol

The following data is based on the product molecular weight 412.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.23 mL 121.16 mL 242.31 mL
0.5 mM 4.85 mL 24.23 mL 48.46 mL
1 mM 2.42 mL 12.12 mL 24.23 mL
5 mM 0.48 mL 2.42 mL 4.85 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for α-Spinasterol

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for α-Spinasterol

For research use only

Related Research Areas

Ion Channels and Regulators

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