Chemical Name: (3β,5α,22E)-Stigmasta-7.22-dien-3-ol
Biological Activityα-Spinasterol is a TRPV1 antagonist (IC50 = 1.4 μM). Reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Brain penetrant and orally bioavailable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties.
Trevisan et al.
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