A neurosteroid anesthetic that directly activates and potentiates GABAA
receptor-activated membrane current (IGABA
). Efficacy but not potency is determined by the alpha subunit of the receptor (EC50
values are 1.4, 1.8, 2.1, 2.4 and 2.5 μ
M for α
2L and α
2L isoforms respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Subunit dependent modulation of GABAA receptor function by neuroactive steroids.
Maitra et al.
Brain Res., 1999;819:75
Auto-modulation of neuroactive steroids on GABAA receptors: a novel pharmacological effect.
Wegner et al.
The involvement of hypothalamic sleep pathways in general anesthesia: Testing the hypothesis using the GABAA receptor β3N265M knock-in mouse.
Zecharia et al.