Chemical Name: (5Z)-5-[[(4-[(2-Methylphenyl)thio]-3-nitrophenyl]methylene]-2-thioxo-4-thiazolidinone
Biological ActivityDNA polymerase λ and β inhibitor (IC50 values are 3.9 and 18.2 μM, respectively). Sensitizes human colorectal cancer cells to hydrogen peroxide and temozolomide (Cat. No. 2706) in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Expanding the scope of human DNA polymerase λ and β inhibitors.
Strittmatter et al.
ACS Chem.Biol., 2014;9:282
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