Catalog Number: 3084
Chemical Name: 2-Hydroxy-6-pentadecylbenzoic acid
Biological Activity
Noncompetitive inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50 values are ~5.0 and ~8.5 μM respectively). Inhibits NF-κB activation. Also reported to selectively activate Aurora kinase A-mediated phosphorylation of histone H3. Exhibits antitumor, antimicrobial and antioxidant activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small molecule modulators of histone acetyltransferase p300.
    Balasubramanyam et al.
    J.Biol.Chem., 2003;278:19134
  2. Specific small molecule activator of aurora kinase A induces autophosphorylation in a cell-free system.
    Kishore et al.
    J.Med.Chem., 2008;51:792
  3. Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the
    Sung et al.
    Blood, 2008;111:4880
  4. Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development.
    Cui et al.
    Eurkaryot.Cell, 2008;7:1200

The citations listed below are publications that use Tocris products. Selected citations for Anacardic acid include:

Showing Results 1 - 1 of 1

  1. Borna disease virus phosphoprotein modulates epigenetic signaling in neurons to control viral replication.
    Authors: Bonnaud Et al.
    PLoS One
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