Noncompetitive inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50
values are ~5.0 and ~8.5 μ
M respectively). Inhibits NF-κ
B activation. Also reported to selectively activate Aurora kinase A-mediated phosphorylation of histone H3. Exhibits antitumor, antimicrobial and antioxidant activity.
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All Tocris products are intended for laboratory research use only.
Small molecule modulators of histone acetyltransferase p300.
Balasubramanyam et al.
Specific small molecule activator of aurora kinase A induces autophosphorylation in a cell-free system.
Kishore et al.
Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the
Sung et al.
Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development.
Cui et al.
The citations listed below are publications that use Tocris products. Selected citations for Anacardic acid include:
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