Anacardic acid

Catalog # Availability Size / Price Qty
Anacardic acid | CAS No. 16611-84-0 | Post-translational Modification Inhibitors
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Description: Noncompetitive PCAF/p300 inhibitor

Chemical Name: 2-Hydroxy-6-pentadecylbenzoic acid

Purity: ≥97%

Product Details
Citations (1)

Biological Activity

Noncompetitive inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50 values are ~5.0 and ~8.5 μM respectively). Inhibits NF-κB activation. Also reported to selectively activate Aurora kinase A-mediated phosphorylation of histone H3 and to inhibit protein SUMOylation. Exhibits antitumor, antimicrobial and antioxidant activity.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small molecule modulators of histone acetyltransferase p300.
    Balasubramanyam et al.
    J.Biol.Chem., 2003;278:19134
  2. Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate.
    Fukuda et al.
    Chem.Biol., 2009;16:133
  3. Specific small molecule activator of aurora kinase A induces autophosphorylation in a cell-free system.
    Kishore et al.
    J.Med.Chem., 2008;51:792
  4. Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the
    Sung et al.
    Blood, 2008;111:4880
  5. Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development.
    Cui et al.
    Eurkaryot.Cell, 2008;7:1200

Product Datasheets

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Citation for Anacardic acid

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