Chemical Name: 2-Hydroxy-6-pentadecylbenzoic acid
Biological ActivityNoncompetitive inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50 values are ~5.0 and ~8.5 μM respectively). Inhibits NF-κB activation. Also reported to selectively activate Aurora kinase A-mediated phosphorylation of histone H3 and to inhibit protein SUMOylation. Exhibits antitumor, antimicrobial and antioxidant activity. Also promotes cardiomyocyte differentiation from mESCs.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecule modulators of histone acetyltransferase p300.
Balasubramanyam et al.
Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate.
Fukuda et al.
Specific small molecule activator of aurora kinase A induces autophosphorylation in a cell-free system.
Kishore et al.
Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the
Sung et al.
Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development.
Cui et al.
Anacardic acid and thyroid hormone enhance cardiomyocytes production from undifferentiated mouse ES cells along functionally distinct pathways.
Re et al.
Citation for Anacardic acid
The citations listed below are publications that use Tocris products. Selected citations for Anacardic acid include:
1 Citation: Showing 1 - 1
Borna disease virus phosphoprotein modulates epigenetic signaling in neurons to control viral replication.
Authors: Bonnaud Et al.
PLoS One 2015;89:5996
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