Catalog Number: 5335
Biological Activity
Potent endogenous vasoconstrictor peptide; derivative of angiotensin (Ang) II. Elicits pressor and renal vasoconstrictor effects in rodents via the AT1 receptor; inhibited by Candesartan (Cat. No. 4791) but not by AT2 receptor ligands in vivo. Displays a similar affinity for AT1 and AT2 receptors as angiotensin II in vitro (Ki values are 1.6 and 2.3 nM at AT1 and AT2 receptors); also increases inositol phosphate accumulation with a similar potency to Ang II (EC50 = 6.7 nM).
Technical Data
  • M.Wt:
    1002.18
  • Formula:
    C49H71N13O10
  • Sequence:
    ARVYIHPF
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    51833-76-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent.
    Yang et al.
    Hypertension, 2011;57:956
  2. Cardiovascular effects of angiotensin A: A novel peptide of the renin-angiotensin system.
    Coutinho et al.
    J.Renin Angiotensin Aldosterone Syst., 2013;15:480
  3. Alamandine: a new member of the angiotensin family.
    Villela et al.
    Curr.Opin.Nephrol.Hypertens., 2014;23:130
Tocris Peptides
Description Application Cat# Citations Images  

Angiotensin II

1158 5  
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