Biological ActivityAngiotensin A is a potent endogenous vasoconstrictor peptide; derivative of angiotensin (Ang) II. Elicits pressor and renal vasoconstrictor effects in rodents via the AT1 receptor; inhibited by Candesartan (Cat. No. 4791) but not by AT2 receptor ligands in vivo. Displays a similar affinity for AT1 and AT2 receptors as angiotensin II in vitro (Ki values are 1.6 and 2.3 nM at AT1 and AT2 receptors); also increases inositol phosphate accumulation with a similar potency to Ang II (EC50 = 6.7 nM).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Alamandine: a new member of the angiotensin family.
Villela et al.
Pressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent.
Yang et al.
Cardiovascular effects of angiotensin A: A novel peptide of the renin-angiotensin system.
Coutinho et al.
J.Renin Angiotensin Aldosterone Syst., 2013;15:480
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