Potent endogenous vasoconstrictor peptide; derivative of angiotensin (Ang) II. Elicits pressor and renal vasoconstrictor effects in rodents via the AT1
receptor; inhibited by Candesartan
(Cat. No. 4791) but not by AT2
receptor ligands in vivo
. Displays a similar affinity for AT1
receptors as angiotensin II in vitro
values are 1.6 and 2.3 nM at AT1
receptors); also increases inositol phosphate accumulation with a similar potency to Ang II (EC50
= 6.7 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Pressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent.
Yang et al.
Cardiovascular effects of angiotensin A: A novel peptide of the renin-angiotensin system.
Coutinho et al.
J.Renin Angiotensin Aldosterone Syst., 2013;15:480
Alamandine: a new member of the angiotensin family.
Villela et al.