Anti- Solanezumab (Anti-Idiotype) Antibody

R&D Systems | Catalog # MAB10124

Recombinant Monoclonal Antibody.
R&D Systems

Key Product Details

Species Reactivity

Multi-Species

Applications

Western Blot, Flow Cytometry, CyTOF-ready

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 2372A
View all Solanezumab Primary Antibodies »

Product Specifications

Immunogen

Full-length Solanezumab

Specificity

Detects Solanezumab in Western blots and direct ELISAs. In Western blots, no cross-reactivity with Trastuzumab and Adalimumab is observed.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Anti- Solanezumab (Anti-Idiotype) Antibody

Detection of Solanezumab antibody by Western Blot.

Detection of Solanezumab by Western Blot.

Western blot shows Solanexumab, Trastuzumab (negative control), and Adalibumab (negative control). PVDF membrane was probed with 1 µg/mL of Rabbit Anti-Anti- Solanezumab (Anti-Idiotype) Monoclonal Antibody (Catalog # MAB10124) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # HAF008). A specific band was detected for Solanezumab at approximately 240 kDa (as indicated). Human IgG is shown as a loading control. This experiment was conducted under non-reducing conditions and using Immunoblot Buffer Group 1.
Detection of Anti-APP (Solanezumab) on Human PBMC antibody by Flow Cytometry.

Detection of Anti-APP (Solanezumab) on Human PBMC by flow cytometry.

Human PBMC were stained with Human anti-Human APP (Solanezumab) Monoclonal Antibody (Catalog # MAB9919), then either (A) Rabbit Anti-Solanezumab (Anti-Idiotype) (Catalog # MAB10124) or (B) normal rabbit IgG (Catalog # MAB1050) followed by APC-conjugated anti-rabbit IgG secondary antibody (Catalog # F0111) and Mouse anti-Human CD14 PE-conjugated Monoclonal Antibody (Catalog # FAB3832P).

Applications for Anti- Solanezumab (Anti-Idiotype) Antibody

Application
Recommended Usage

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Flow Cytometry

0.25 µg/106 cells
Sample: Human PBMCs stained with Human anti-Human APP (Solanezumab), Catalog # MAB9919

Western Blot

1 µg/mL
Sample: Solanezumab 
Under non-reducing conditions only

Flow Cytometry Panel Builder

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Advanced Features

  • Spectra Viewer - Custom analysis of spectra from multiple fluorochromes
  • Spillover Popups - Visualize the spectra of individual fluorochromes
  • Antigen Density Selector - Match fluorochrome brightness with antigen density
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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Protein A or G purified from cell culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Solanezumab

The anti-Solanezumab antibody is an anti-Idiotype antibody raised against and selected for the antigenic determinants of the variable region of Solanezumab. The antibody has been tested against a broad range of other biosimilars to ensure specificity. This highly specialized anti-idiotypic antibody can be used in a variety of pharmacokinetic (PK) assay formats.

Additional Solanezumab Products

Product Documents for Anti- Solanezumab (Anti-Idiotype) Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Anti- Solanezumab (Anti-Idiotype) Antibody

For research use only

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FAQs for Anti- Solanezumab (Anti-Idiotype) Antibody

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  • Q: What is an anti-idiotype antibody?

    A: An anti-idiotype antibody is specific for the unique variable (antigen binding) region of another antibody.  We have anti-idiotype antibodies to commecially available therapeutic antibodies or  biosimilars.

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