Apamin

Tocris Bioscience | Catalog # 1652

KCa2 (SK) channel blocker
Tocris Bioscience

Key Product Details

Description

KCa2 (SK) channel blocker
View all Ca2+-Activated Potassium Channel Blockers »

Product Description

Apamin is a potent and highly selective inhibitor of small-conductance Ca2+-activated K+-channels (KCa2, SK) (IC50 values are 87.7 pM, 2.3 nM and 4.1 nM for KCa2.2, KCa2.3 and KCa2.1 channels, respectively). Reduces release and mRNA expression of inflammatory cytokines TNFα and IL-6. In models of kidney and cardiovascular disease apamin ameliorates tissue injury and dysfunction. Brain penetrant, blocks medium after-hyperpolarization in vitro, reduces neuroinflammation, increases microglia node contacts and Purkinje cell instananeous firing frequency.

Product Specifications for Apamin

Molecular Weight

2027.34

Formula

C79H131N31O24S4

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

24345-16-2

PubChem ID

16133797

InChI Key

YVIIHEKJCKCXOB-STYWVVQQSA-N

SMILES

[H]N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC2=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC2=CNC=N2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 200 publications citing the usage of this product.

Product Documents for Apamin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Apamin

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Apamin (1)

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  • Product is a potent SK channel blocker which was studied on BK channels
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/29/2018
    Apamin is a potent SK channel blocker which was studied on BK channels. At low concentrations, it shows minimal blocking effect on BK channels but at higher concentrations moderate effects are shown. Great product and would recommend.
    Apamin 1652

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