Catalog Number: 1652
Biological Activity
Prototypical potent and highly selective inhibitor of the small-conductance Ca2+-activated K+-channel (KCa2, SK). Blocks medium after-hyperpolarization in vitro and is brain penetrant and convulsive in vivo.
Technical Data
  • M.Wt:
    2027.34
  • Formula:
    C79H131N31O24S4
  • Sequence:
    CNCKAPETALCARRCQQH

    (Modifications: Disulfide bridge between 1 - 11, 3 - 15, His-18 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    24345-16-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Apamin.
    Habermann
    Pharmacol.Ther., 1984;25:255
  2. Matching molecules to function: neuronal Ca2+-activated K+ channels and afterhyperpolarizations.
    Stocker et al.
    Toxicon, 2004;43:933
  3. Potassium channel toxins.
    Strong
    Pharmacol.Ther., 1990;46:137
  4. Behavioral effects of apamin, a selective inhibitor of the SKCa-channel, in mice and rats.
    van der Staay et al.
    Neurosci.Biobehav.Rev., 1999;23:1087
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Apamin include:

18 Citations: Showing 1 - 10
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  1. Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels
    Authors: Sargin Et al.
    Elife 2016;5:e21416
  2. Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss.
    Authors: Henry Et al.
    Mol Pain 2015;4
  3. Increased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress.
    Authors: Rau Et al.
    Heart Rhythm 2015;35:9730
  4. Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss.
    Authors: Zachary and Fuchs
    J Neurosci 2015;35:9701
  5. The role of K+ conductances in regulating membrane excitability in human gastric corpus smooth muscle.
    Authors: Lee Et al.
    FASEB J 2015;308:G625
  6. Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain.
    Authors: Thompson Et al.
    J Neurosci 2015;11:51
  7. Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents.
    Authors: Yu Et al.
    J Neurosci 2014;9:e96691
  8. Amiodarone inhibits apamin-sensitive potassium currents.
    Authors: Turker Et al.
    PLoS One 2013;8:e70450
  9. Synaptic NMDA receptor-dependent Ca2+ entry drives membrane potential and Ca2+ oscillations in spinal ventral horn neurons.
    Authors: Alpert and Alford
    PLoS One 2013;8:e63154
  10. Proarrhythmic effect of blocking the small conductance calcium activated potassium channel in isolated canine left atrium.
    Authors: Hsueh Et al.
    Elife 2013;10:891
  11. Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release.
    Authors: Few Et al.
    Proc Natl Acad Sci U S A 2012;109:E452
  12. Dynamic interplay of excitatory and inhibitory coupling modes of neuronal L-type calcium channels.
    Authors: Geier Et al.
    Am J Physiol Cell Physiol 2011;300:C937
  13. Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferator-activated receptor-γ.
    Authors: Chan and Cipolla
    Sci Rep 2011;25:3229
  14. Postnatal expression of an apamin-sensitive k(ca) current in vestibular calyx terminals.
    Authors: Meredith Et al.
    J Membr Biol 2011;244:81
  15. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
    Endocrinology 2011;152:3842
  16. Visinin-like neuronal calcium sensor proteins regulate the slow calcium-activated afterhyperpolarizing current in the rat cerebral cortex.
    Authors: Villalobos and Andrade
    Am J Physiol Gastrointest Liver Physiol 2010;30:14361
  17. Allosteric block of KCa2 channels by apamin.
    Authors: Lamy Et al.
    J Neurosci 2010;285:27067
  18. Dopaminergic modulation of spinal neuronal excitability.
    Authors: Han Et al.
    J Biol Chem 2007;27:13192
Expand to show all 18 Citations

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