Apamin

  ( 19 citations )    
Product Datasheet
Catalog Number:1652
Chemical Name:
Product Details
Citations (19)
Reviews
Biological Activity
Prototypical potent and highly selective inhibitor of the small-conductance Ca2+-activated K+-channel (KCa2, SK). Blocks medium after-hyperpolarization in vitro and is brain penetrant and convulsive in vivo.
Technical Data
  • M.Wt:
    2027.34
  • Formula:
    C79H131N31O24S4
  • Sequence:
    CNCKAPETALCARRCQQH

    (Modifications: Disulfide bridge between 1 - 11, 3 - 15, His-18 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    24345-16-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Apamin include:

19 Citations: Showing 1 - 10
Filter your results:

  1. Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels
    Authors: Sargin Et al.
    Elife  2016;5:e21416
  2. Cyclooxygenase-2 inhibition reduces stress-induced affective pathology.
    Authors: Gamble-George Et al.
    Elife  2016;5
  3. Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss.
    Authors: Henry Et al.
    Mol Pain  2015;4
  4. Increased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress.
    Authors: Rau Et al.
    Heart Rhythm  2015;35:9730
  5. Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss.
    Authors: Zachary and Fuchs
    J Neurosci  2015;35:9701
  6. The role of K+ conductances in regulating membrane excitability in human gastric corpus smooth muscle.
    Authors: Lee Et al.
    FASEB J  2015;308:G625
  7. Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain.
    Authors: Thompson Et al.
    J Neurosci  2015;11:51
  8. Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents.
    Authors: Yu Et al.
    J Neurosci  2014;9:e96691
  9. Amiodarone inhibits apamin-sensitive potassium currents.
    Authors: Turker Et al.
    PLoS One  2013;8:e70450
  10. Synaptic NMDA receptor-dependent Ca2+ entry drives membrane potential and Ca2+ oscillations in spinal ventral horn neurons.
    Authors: Alpert and Alford
    PLoS One  2013;8:e63154
  11. Proarrhythmic effect of blocking the small conductance calcium activated potassium channel in isolated canine left atrium.
    Authors: Hsueh Et al.
    Elife  2013;10:891
  12. Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release.
    Authors: Few Et al.
    Proc Natl Acad Sci U S A  2012;109:E452
  13. Dynamic interplay of excitatory and inhibitory coupling modes of neuronal L-type calcium channels.
    Authors: Geier Et al.
    Am J Physiol Cell Physiol  2011;300:C937
  14. Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferator-activated receptor-γ.
    Authors: Chan and Cipolla
    Sci Rep  2011;25:3229
  15. Postnatal expression of an apamin-sensitive k(ca) current in vestibular calyx terminals.
    Authors: Meredith Et al.
    J Membr Biol  2011;244:81
  16. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
    Endocrinology  2011;152:3842
  17. Visinin-like neuronal calcium sensor proteins regulate the slow calcium-activated afterhyperpolarizing current in the rat cerebral cortex.
    Authors: Villalobos and Andrade
    Am J Physiol Gastrointest Liver Physiol  2010;30:14361
  18. Allosteric block of KCa2 channels by apamin.
    Authors: Lamy Et al.
    J Neurosci  2010;285:27067
  19. Dopaminergic modulation of spinal neuronal excitability.
    Authors: Han Et al.
    J Biol Chem  2007;27:13192
Expand to show all Citations

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Have you used Apamin?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee