APH1A Antibody

Novus Biologicals | Catalog # NB100-74360

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Western Blot, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Chromatin Immunoprecipitation (ChIP)

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all APH1A Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptide, KLH conjugated, corresponding to residues C (245) R R Q E D S R V M V Y S A L R I P P E D (265) of human APH-1aL/CT.

Specificity

APH-1

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for APH1A Antibody

Western Blot: APH1A Antibody [NB100-74360]

Western Blot: APH1A Antibody [NB100-74360]

Western Blot: APH1A Antibody [NB100-74360] - Analysis of mouse brain and kidney extracts.
Immunocytochemistry/ Immunofluorescence: APH1A Antibody [NB100-74360]

Immunocytochemistry/ Immunofluorescence: APH1A Antibody [NB100-74360]

Immunocytochemistry/Immunofluorescence: APH1A Antibody [NB100-74360] - Staining of APH-1 in human KNS-42 glioma cells.

Applications for APH1A Antibody

Application
Recommended Usage

Chromatin Immunoprecipitation (ChIP)

1:10-1:500

Immunocytochemistry/ Immunofluorescence

1:100

Immunohistochemistry

1:10 - 1:500

Immunohistochemistry-Frozen

1:10 - 1:500

Immunohistochemistry-Paraffin

1:10 - 1:500

Immunoprecipitation

1:10 - 1:500

Western Blot

1:1000
Application Notes
WB: Detects an approx. 18 kDa protein representing APH-1 in mouse brain and kidney extracts. ChIP usage was reported in the scientific literature (PMID: 20145246).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.005% Sodium Azide

Concentration

0.69 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: APH1A

Anterior Pharynx Defective 1 (APH1a) is an integral transmembrane protein forming a component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein).

Long Name

gamma-Secretase Subunit Anterior Pharynx Defective 1 Homolog A

Alternate Names

6530402N02Rik, anterior pharynx defective 1 homolog A (C. elegans), APH-1, APH-1A, Aph-1alpha, CGI-78, gamma-secretase subunit APH-1A, Presenilin-stabilization factor, PSF

Entrez Gene IDs

51107 (Human); 235606 (Mouse)

Gene Symbol

APH1A

UniProt

Q96BI3

Additional APH1A Products

Product Documents for APH1A Antibody

Certificate of Analysis

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Product Specific Notices for APH1A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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