Non-peptidic, low-internalizing δ
-selective opioid receptor agonist; derivative of SNC 80
(Cat. No. 0764). Does not trigger acute desensitization of the analgesic response; reduces CFA-induced hyperalgesia. Brain penetrant following systemic administration.
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All Tocris products are intended for laboratory research use only.
Pharmacological characterization of AR-M1000390 at human opioid delta receptors.
Marie et al.
Life Sci., 2003;73:1691
Ligand-directed trafficking of the δ-opioid receptor in vivo: Two paths toward analgesic tolerance.
Pradhan et al.