Arachidonic acid (in Tocrisolve™100)
Chemical Name: 5Z,8Z,11Z,14Z-Eicosatetraenoic acid
Biological ActivityEndogenous free fatty acid released from phospholipids by phospholipase A2, in water-soluble emulsion (for details see TocrisolveTM 100, Cat. No. 1684). Important cellular signaling mediator and precursor of eicosanoids. Metabolized by lipoxygenases, cyclooxygenases and cytochrome P450 monooxygenases.
Tocrisolve Control also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Roles of cPLA2α and arachidonic acid in cancer.
Nakanishi et al.
Arachidonic acid metabolism as a potential mediator of cardiac fibrosis associated with inflammation.
Levick et al.
Arachidonic acid promotes glutamate-induced cell death associated with necrosis by 12-lipoxygenase activation in glioma cells.
Higuchi et al.
Life Sci., 2007;80:1856
Citations for Arachidonic acid (in Tocrisolve™100)
The citations listed below are publications that use Tocris products. Selected citations for Arachidonic acid (in Tocrisolve™100) include:
2 Citations: Showing 1 - 2
Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
Authors: Park Et al.
Nat Immunol 2016;17:914
Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism.
Authors: Hamtiaux Et al.
PLoS One 2011;6:e26823
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