Catalog Number: 1684
Biological Activity
Water soluble emulsion composed of a 1:4 ratio of soya oil/water that is emulsified with the block co-polymer Pluronic F68. Can be diluted with any aqueous medium. Used to solubilize hydrophobic organic chemicals and water-insoluble lipids such as cannabinoids and vanilloids. The cannabinoid or vanilloid is incorporated with the emulsion as part of a specialized innovative production process. The soya oil forms a coating around the cannabinoid molecule, and the block co-polymer is added to stabilize the emulsion, preventing the lipid droplets from coalescing (merging) in the surrounding water. Also can be used as a negative control for reagents in TocrisolveTM 100; Anandamide, AM 404, VDM 11, ACPA, (R)-(+)-Methanandamide, JWH 133 and Arachidonic acid (Cat. Nos. 1017, 1685, 1686, 1781, 1782, 1783 and 2756 respectively).
Technical Data
  • Storage:
    Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Chronic topical administration of WIN-55-212-2 maintains a reduction in IOP in a rat glaucoma model without adverse effects.
    Hosseini et al.
    Exp.Eye Res., 2006;82:753
  2. Topical WIN55212-2 alleviates intraocular hypertenision in rats through a CB1 receptor mediated mechanism of action.
    Oltmanns et al.
    J.Ocul.Pharmacol.Ther., 2008;24:104
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Tocrisolve™ 100 include:

Showing Results 1 - 10 of 15

  1. Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury.
    Authors: Hwang Et al.
    J Neuroinflammation
  2. Cytoprotective Effects of Lysophospholipids from Sea Cucumber Holothuria atra.
    Authors: Nishikawa Et al.
    Br J Pharmacol
  3. Anti-inflammatory effects of cannabinoid CB(2) receptor activation in endotoxin-induced uveitis.
    Authors: Toguri Et al.
    Behav Brain Res
  4. Cannabinoid receptor type-2 stimulation, blockade, and deletion alters the vascular inflammatory responses to traumatic brain injury.
    Authors: Amenta Et al.
    PLoS One
  5. Electroacupuncture modulation of reflex hypertension in rats: role of cholecystokinin octapeptide.
    Authors: Li Et al.
    Am J Physiol Regul Integr Comp Physiol
  6. Treatment with CB2 agonist JWH-133 reduces histological features associated with erectile dysfunction in hypercholesterolemic mice.
    Authors: Fraga-Silva Et al.
    Clin Dev Immunol
  7. The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques.
    Authors: Montecucco Et al.
    Br J Pharmacol
  8. Inhibition of GSK3 attenuates amphetamine-induced hyperactivity and sensitization in the mouse.
    Authors: Enman and Unterwald
    J Neurosci
  9. Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy.
    Authors: Wyeth Et al.
    J Neurosci
  10. Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex.
    Authors: Ho Et al.
    Br J Pharmacol
  11. Effect of the CB(1) receptor antagonists rimonabant and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices.
    Authors: Mendiguren and Pineda
    Br J Pharmacol
  12. Differential endocannabinoid regulation of baroreflex-evoked sympathoinhibition in normotensive versus hypertensive rats.
    Authors: Brozoski Et al.
    Auton Neurosci
  13. Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA.
    Authors: Tjen-A-Looi Et al.
    J Appl Physiol (1985)
  14. Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression.
    Authors: Esposito Et al.
    Br J Pharmacol
  15. Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats.
    Authors: Gaskari Et al.
    Eur Heart J
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